C57BL/6JCya-Mrrfem1flox/Cya
Common Name
Mrrf-flox
Product ID
S-CKO-13929
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-67871-Mrrf-B6J-VA
Status
When using this mouse strain in a publication, please cite “Mrrf-flox Mouse (Catalog S-CKO-13929) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Mrrf-flox
Strain ID
CKOCMP-67871-Mrrf-B6J-VA
Gene Name
Product ID
S-CKO-13929
Gene Alias
RRF, MRFF, MTRRF, 2400002D02Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000028250
NCBI RefSeq
NM_026422
Target Region
Exon 4
Size of Effective Region
~1.6 kb
Overview of Gene Research
Mrrf, known as the human mitochondrial ribosome recycling factor, is crucial for the process of translation in mitochondria. Mitochondrial translation is essential for the synthesis of proteins involved in oxidative phosphorylation, a key metabolic pathway that generates ATP, the energy currency of the cell. Thus, Mrrf plays a vital role in maintaining mitochondrial function and overall cellular energy metabolism [1].
No information regarding KO/CKO mouse models or loss-of-function experiments was found in the provided references.
In conclusion, Mrrf is essential for mitochondrial translation, which is crucial for energy-generating oxidative phosphorylation. Although no model-based research findings were available from the given references, understanding Mrrf's function is key to comprehending mitochondrial function and its potential implications in energy-related diseases.
References：
1. Hansen, L L, Jørgensen, R, Justesen, J. . Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. In Cytogenetics and cell genetics, 88, 91-2. doi:. https://pubmed.ncbi.nlm.nih.gov/10773675/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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