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C57BL/6JCya-Cthrc1em1flox/Cya
Common Name:
Cthrc1-flox
Product ID:
S-CKO-14227
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cthrc1-flox
Strain ID
CKOCMP-68588-Cthrc1-B6J-VA
Gene Name
Cthrc1
Product ID
S-CKO-14227
Gene Alias
1110014B07Rik
Background
C57BL/6JCya
NCBI ID
68588
Modification
Conditional knockout
Chromosome
15
Phenotype
MGI:1915838
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cthrc1em1flox/Cya mice (Catalog S-CKO-14227) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067072
NCBI RefSeq
NM_026778
Target Region
Exon 2~3
Size of Effective Region
~4.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
CTHRC1, or Collagen Triple Helix Repeat Containing 1, is a secreted glycoprotein. It plays a pivotal role in extracellular matrix (ECM) deposition and wound repair, and is a primary target of TGF-β signaling in fibrosis. CTHRC1 also modulates both the TGF-β and canonical Wnt signaling pathways, regulating tissue remodeling and homeostasis [1]. It is involved in various physiological processes such as metabolism, arterial remodeling, bone formation, and peripheral nervous system myelination [4].

In liver fibrosis, CTHRC1, derived from hepatic stellate cells (HSCs), promotes HSCs transformation to an activated state and enhances their migratory or contractile capacities by activating TGF-β signaling. CCl4 or TAA-induced liver fibrosis was attenuated in CTHRC1 -/- mice, and a monoclonal antibody of CTHRC1 suppressed liver fibrosis in wild-type mice, suggesting CTHRC1 as a regulator of liver fibrosis and a potential therapeutic target [2]. In the context of myocardial infarction, absence of CTHRC1 in mice led to pronounced lethality due to ventricular rupture, highlighting its role in the healing scar process [3]. Also, Cthrc1 deficiency in mice aggravated cardiac function, reduced collagen deposition, and increased mortality from cardiac rupture after myocardial infarction, and these effects could be partly reversed by rCTHRC1 or rWNT5A protein, indicating CTHRC1's role in wound repair and preventing cardiac rupture via the non-canonical WNT5A-PCP signaling pathway [5].

In conclusion, CTHRC1 is crucial for ECM deposition, wound repair, and tissue homeostasis. Studies using gene knockout mouse models have revealed its significant roles in fibrotic diseases such as liver fibrosis and in post-myocardial infarction wound repair. These findings suggest CTHRC1 as a potential biomarker and therapeutic target for related diseases.

References:
1. Mukhatayev, Zhussipbek, Adilbayeva, Altynay, Kunz, Jeannette. 2024. CTHRC1: An Emerging Hallmark of Pathogenic Fibroblasts in Lung Fibrosis. In Cells, 13, . doi:10.3390/cells13110946. https://pubmed.ncbi.nlm.nih.gov/38891078/
2. Li, Jun, Wang, Yahui, Ma, Mingze, Xu, Qing, Zhang, Zhigang. 2019. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. In EBioMedicine, 40, 43-55. doi:10.1016/j.ebiom.2019.01.009. https://pubmed.ncbi.nlm.nih.gov/30639416/
3. Ruiz-Villalba, Adrián, Romero, Juan P, Hernández, Silvia C, Lara-Astiaso, David, Prósper, Felipe. 2020. Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. In Circulation, 142, 1831-1847. doi:10.1161/CIRCULATIONAHA.119.044557. https://pubmed.ncbi.nlm.nih.gov/32972203/
4. Liu, Ya-Juan, Du, Jing, Li, Jie, Tan, Xiao-Ping, Zhang, Qing. 2023. CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review). In Oncology letters, 25, 266. doi:10.3892/ol.2023.13852. https://pubmed.ncbi.nlm.nih.gov/37216164/
5. Wang, Di, Zhang, Yaping, Ye, Tianbao, Jin, Xian, Shen, Chengxing. 2023. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway. In International journal of biological sciences, 19, 1299-1315. doi:10.7150/ijbs.79260. https://pubmed.ncbi.nlm.nih.gov/36923925/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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