C57BL/6JCya-Pscaem1flox/Cya
Common Name
Psca-flox
Product ID
S-CKO-15452
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-72373-Psca-B6J-VA
When using this mouse strain in a publication, please cite “Psca-flox Mouse (Catalog S-CKO-15452) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Psca-flox
Strain ID
CKOCMP-72373-Psca-B6J-VA
Gene Name
Product ID
S-CKO-15452
Gene Alias
2210408B04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023265
NCBI RefSeq
NM_028216
Target Region
Exon 2~3
Size of Effective Region
~2.4 kb
Overview of Gene Research
PSCA, short for Prostate Stem Cell Antigen, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. It has diverse functions in different tissues, such as playing an inhibitory role in cell proliferation as well as a tumor-inducing role. PSCA is involved in the p38/NF-κB/IL-6 signaling pathway, positively regulating IL-6 secretion in prostate cancer cells [2,5].
Variants in the PSCA gene have been associated with the risk of multiple cancers and non-neoplastic diseases. For example, six variants were significantly associated with an increased or reduced risk of three cancers and three non-neoplastic diseases. Cumulative evidence shows strong associations between certain variants like rs2294008, rs2976392, etc., and gastric cancer, bladder cancer, gastritis, duodenal ulcer, and gastric ulcer [3]. In addition, the PSCA rs2294008 T polymorphism is related to increased cancer susceptibility, especially for gastric and bladder cancers [6].
CAR-T cell therapies targeting PSCA are being explored in metastatic castration-resistant prostate cancer, metastatic pancreatic cancer, and gastric cancer. Some clinical trials show certain efficacy, such as prostate-specific antigen declines and radiographic improvements in prostate cancer patients, and anti-tumor cytotoxicity in vitro and in vivo in gastric cancer models [1,4,7].
In conclusion, PSCA is a cell-surface protein with complex functions, and its gene variants are associated with cancer and non-neoplastic disease risks. The use of PSCA as a therapeutic target in CAR-T cell therapies shows potential in treating various cancers. The study of PSCA through genetic models helps in understanding disease pathogenesis and developing new treatment strategies.
References：
1. Dorff, Tanya B, Blanchard, M Suzette, Adkins, Lauren N, Forman, Stephen J, Priceman, Saul J. 2024. PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial. In Nature medicine, 30, 1636-1644. doi:10.1038/s41591-024-02979-8. https://pubmed.ncbi.nlm.nih.gov/38867077/
2. Nayerpour Dizaj, Tina, Doustmihan, Abolfazl, Sadeghzadeh Oskouei, Behnaz, Mazloomi, MirAhmad, Jahanban-Esfahlan, Rana. 2024. Significance of PSCA as a novel prognostic marker and therapeutic target for cancer. In Cancer cell international, 24, 135. doi:10.1186/s12935-024-03320-6. https://pubmed.ncbi.nlm.nih.gov/38627732/
3. Cui, Huijie, Tang, Mingshuang, Zhang, Min, Gu, Dongqing, Zhang, Ben. . Variants in the PSCA gene associated with risk of cancer and nonneoplastic diseases: systematic research synopsis, meta-analysis and epidemiological evidence. In Carcinogenesis, 40, 70-83. doi:10.1093/carcin/bgy151. https://pubmed.ncbi.nlm.nih.gov/30407486/
4. Stein, Mark N, Dumbrava, Ecaterina E, Teply, Benjamin A, Stadler, Walter M, Becerra, Carlos R. 2024. PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial. In Nature communications, 15, 10743. doi:10.1038/s41467-024-53220-6. https://pubmed.ncbi.nlm.nih.gov/39737899/
5. Liu, Luhao, Li, Ermao, Luo, Lianmin, Luo, Jintai, Zhao, Zhigang. 2017. PSCA regulates IL-6 expression through p38/NF-κB signaling in prostate cancer. In The Prostate, 77, 1389-1400. doi:10.1002/pros.23399. https://pubmed.ncbi.nlm.nih.gov/28845520/
6. Wang, Xiao-Feng, Liu, Dong-Li, Geng, Li. . The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis. In Genetic testing and molecular biomarkers, 27, 44-55. doi:10.1089/gtmb.2022.0067. https://pubmed.ncbi.nlm.nih.gov/36853840/
7. Wu, Di, Lv, Jiang, Zhao, Ruocong, Li, Peng, Yao, Yao. 2020. PSCA is a target of chimeric antigen receptor T cells in gastric cancer. In Biomarker research, 8, 3. doi:10.1186/s40364-020-0183-x. https://pubmed.ncbi.nlm.nih.gov/32010446/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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