C57BL/6JCya-3110082I17Rikem1flox/Cya
Common Name:
3110082I17Rik-flox
Product ID:
S-CKO-15650
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
3110082I17Rik-flox
Strain ID
CKOCMP-73212-3110082I17Rik-B6J-VA
Gene Name
Product ID
S-CKO-15650
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-3110082I17Rikem1flox/Cya mice (Catalog S-CKO-15650) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000066052
NCBI RefSeq
NM_028469
Target Region
Exon 3
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
3110082I17Rik, the mouse ortholog of human C7orf50, encodes a hormone named Cholesin. This gene is crucial for cholesterol homeostasis as the hormone it encodes is involved in the regulation of cholesterol metabolism pathways. Understanding its function is vital for comprehending cholesterol-related biological processes, and mouse models are valuable genetic tools for its study.
Research has identified that Cholesin, encoded by 3110082I17Rik, is secreted from the intestine in response to cholesterol absorption. It binds to GPR146, an orphan G-protein-coupled receptor, and inhibits PKA signaling. This, in turn, suppresses SREBP2-controlled cholesterol synthesis in the liver, demonstrating that the Cholesin-GPR146 axis mediates the inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis [1].
In conclusion, 3110082I17Rik is essential for regulating cholesterol metabolism through the production of Cholesin. The use of mouse models has revealed its role in maintaining cholesterol homeostasis. Given its function, 3110082I17Rik holds promise in combating hypercholesterolemia and atherosclerosis, providing new insights into potential therapeutic strategies for these cholesterol-related diseases [1].
References:
1. Hu, Xiaoli, Chen, Fengyi, Jia, Liangjie, Zhang, Huijie, Wang, Yiguo. 2024. A gut-derived hormone regulates cholesterol metabolism. In Cell, 187, 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. https://pubmed.ncbi.nlm.nih.gov/38503280/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen