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C57BL/6JCya-Cep43em1flox/Cya
Common Name:
Cep43-flox
Product ID:
S-CKO-16194
Background:
C57BL/6JCya
Product Type
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Basic Information
Strain Name
Cep43-flox
Strain ID
CKOCMP-75296-Cep43-B6J-VA
Gene Name
Cep43
Product ID
S-CKO-16194
Gene Alias
4930553O10Rik; FOP; Fgfr1op
Background
C57BL/6JCya
NCBI ID
75296
Modification
Conditional knockout
Chromosome
17
Phenotype
MGI:1922546
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cep43em1flox/Cya mice (Catalog S-CKO-16194) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000097419
NCBI RefSeq
NM_001197046
Target Region
Exon 3
Size of Effective Region
~0.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cep43, a gene with no common aliases mentioned in the provided references, plays a crucial role in cilia-related processes. Cilia are important organelles for cell signaling and locomotion, constructed via intraflagellar transport (IFT). Cep43 is involved in the assembly of IFT complexes into IFT trains for ciliary entry [1].

Structural modeling indicates that the N-terminal domain of Cep43 forms a homo-dimer. It anchors at the subdistal appendages of cilia through a direct interaction with CEP350. A long linker separates this N-terminal domain from the C-terminal domain, which captures CEP19 above the subdistal appendages and close to the distal appendages. This architecture provides a framework for how RabL2 is anchored at the ciliary base via CEP19 before being handed over to IFT trains for ciliary entry [1].

In conclusion, Cep43 is essential for the proper structural organization and function of cilia, specifically in the processes related to the anchoring and transfer of components for ciliary entry. Although no KO/CKO mouse models were mentioned in the references, the structural insights into Cep43's role in ciliary processes contribute to our understanding of cilia-associated biological functions and potentially related diseases.

References:
1. Boegholm, Niels, Petriman, Narcis A, Tanvir, Niaj M, Lorentzen, Esben. 2024. Architecture of RabL2-associated complexes at the ciliary base: A structural modeling perspective: Deciphering the structural organization of ciliary RabL2 complexes. In BioEssays : news and reviews in molecular, cellular and developmental biology, 46, e2300222. doi:10.1002/bies.202300222. https://pubmed.ncbi.nlm.nih.gov/38991980/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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