Pcdhb6, a member of the protocadherin beta gene cluster, is likely involved in cell-cell adhesion processes as it has been associated with pathways related to this function [2]. Genes in this cluster are thought to play roles in neural development and function, and Pcdhb6 may contribute to these broader biological processes. Animal models, especially mice, can be valuable for studying Pcdhb6 function.

In a study on hepatocellular carcinoma (HCC), subclass HCCW4, which was associated with a poor prognosis, had the highest Pcdhb6 expression, along with a relatively high abundance of certain immune cells and high Edmondson-Steiner grades (III and IV) [1]. In a mouse model of partial monosomy 21, deletion of the App-Runx1 region led to disruptions of pathways related to cell adhesion, with Pcdhb6 being among the genes involved, and the mice displayed phenotypes similar to human partial monosomy 21 [2]. In a study of Baiyu and Chuanzhong black goats, Pcdhb6 was identified as one of the genes related to neurodevelopment [3]. In a GWAS for milk protein composition traits in Chinese Holstein cows, Pcdhb6 was proposed as a novel candidate gene affecting these traits [4].

In conclusion, Pcdhb6 appears to be involved in multiple biological processes such as cell adhesion, neurodevelopment, and potentially in determining disease-related phenotypes. Its role in hepatocellular carcinoma prognosis and in the context of partial monosomy 21-like phenotypes in mice, as well as in goat neurodevelopment and cow milk protein traits, showcases its significance across different species and disease/biological contexts.