C57BL/6JCya-Tm2d1em1flox/Cya
Common Name:
Tm2d1-flox
Product ID:
S-CKO-17216
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Tm2d1-flox
Strain ID
CKOCMP-94043-Tm2d1-B6J-VA
Gene Name
Product ID
S-CKO-17216
Gene Alias
2310026L18Rik; Bbp
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tm2d1em1flox/Cya mice (Catalog S-CKO-17216) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102793
NCBI RefSeq
NM_053157
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Tm2d1, also known as β -amyloid peptide binding protein, is involved in important biological processes. It is critical to the pathogenesis of Alzheimer's disease and has potential connections with cancer-related processes [1,4,5].
In hepatocellular carcinoma (HCC), TM2D1 is increasingly expressed in tumors relative to peritumoral tissues. Overexpression of TM2D1 induces HCC cell proliferation, migration, and invasion, related to epithelial-mesenchymal transition (EMT), by promoting Akt and β-catenin hyper-activation. Depletion of TM2D1 leads to the opposite phenotype [1].
In colorectal cancer, sevoflurane and propofol co-treatment exerts anti-tumor activities, and TM2D1 is considered a target of these anesthetics. Overexpression of TM2D1 reverses the anti-tumor effects of sevoflurane and propofol on colorectal cancer cell biology behaviors [2].
In cattle and buffalo preantral follicles, the expression of TM2D1 was detected in the study of genes associated with apoptosis, indicating its possible role in follicular development [3].
In conclusion, TM2D1 plays important roles in cancer-related biological processes such as cell proliferation, migration, invasion, and EMT, as well as in follicular development. The findings from studies on TM2D1 contribute to understanding the mechanisms of these diseases and biological processes, potentially providing new therapeutic targets for cancer treatment.
References：
1. Hu, Jin-Wu, Yin, Yue, Gao, Yang, Fan, Jia, Zhou, Jian. 2021. TM2D1 contributes the epithelial-mesenchymal transition of hepatocellular carcinoma via modulating AKT/β-catenin axis. In American journal of cancer research, 11, 1557-1571. doi:. https://pubmed.ncbi.nlm.nih.gov/33948373/
2. Lu, Yan, Li, Ling, Piao, Zongfang, Tan, Xinmin, Su, Rui. 2024. Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1. In Combinatorial chemistry & high throughput screening, , . doi:10.2174/0113862073281046240527165415. https://pubmed.ncbi.nlm.nih.gov/38920064/
3. Zoheir, Khairy Mohamed, Darwish, Ahmed Mohamed, Liguo, Yang, Ashour, Abdelkader E. 2021. Transcriptome comparisons detect new genes associated with apoptosis of cattle and buffaloes preantral follicles. In Journal, genetic engineering & biotechnology, 19, 151. doi:10.1186/s43141-021-00253-9. https://pubmed.ncbi.nlm.nih.gov/34623529/
4. Lee, Yong, Chang, Deok-Jin, Lee, Yong-Seok, Suh, Yoo-Hun, Kaang, Bong-Kiun. . Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. In Journal of neuroscience research, 73, 255-9. doi:. https://pubmed.ncbi.nlm.nih.gov/12836168/
5. Kajkowski, E M, Lo, C F, Ning, X, Jacobsen, J S, Ozenberger, B A. 2001. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. In The Journal of biological chemistry, 276, 18748-56. doi:. https://pubmed.ncbi.nlm.nih.gov/11278849/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen