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C57BL/6JCya-Lbpem1flox/Cya
Common Name:
Lbp-flox
Product ID:
S-CKO-17881
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lbp-flox
Strain ID
CKOCMP-16803-Lbp-B6J-VB
Gene Name
Lbp
Product ID
S-CKO-17881
Gene Alias
Bpifd2; Ly88
Background
C57BL/6JCya
NCBI ID
16803
Modification
Conditional knockout
Chromosome
2
Phenotype
MGI:1098776
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lbpem1flox/Cya mice (Catalog S-CKO-17881) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000016168
NCBI RefSeq
NM_008489
Target Region
Exon 2
Size of Effective Region
~0.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lbp, short for Lipopolysaccharide-binding protein, is a significant protein in the host's innate immune defense. It binds to bacterial lipopolysaccharide (LPS), transfers LPS to its cellular receptor or lipoproteins, and also interacts with other bacterial compounds like lipoteichoic acid (LTA) and lipopeptides, modulating the host's innate immune system [2]. Lbp is synthesized in hepatocytes and secreted into the bloodstream, and its levels rise substantially during the acute-phase response [4].

In a rat sepsis model, deletion of Lbp reduced LPS-induced liver inflammation and injury at 1 and 6 h, but at 24 h, mitochondrial damage and reactive oxygen species (ROS) levels were higher in Lbp-/-rat livers compared to wild-type (WT) rat livers. Lbp protects hepatic mitochondria against LPS-induced damage via the Lbp-PPARα-CYP4a2 signaling pathway [1]. In Trachinotus ovatus, ToBPI1/LBP and ToBPI2/LBP (two BPI/LBPs) were significantly expressed in immune-related tissues after being challenged with bacteria, showing antibacterial activity against certain Gram-negative and Gram-positive bacteria [3]. Also, TroBPI/LBP from Trachinotus ovatus was constitutively expressed in tested tissues, with the highest expression in the liver. Its mRNA expression was upregulated in immune-related tissues after Vibrio alginolyticus stimulation, and overexpression of TroBPI/LBP enhanced the fish's ability to resist V. alginolyticus infection while knockdown diminished bacterial clearance capacity [5].

In conclusion, Lbp plays a crucial role in the innate immune defense against bacterial infections and in protecting hepatocyte mitochondrial function during sepsis. Gene knockout models in rats and fish have revealed its importance in specific biological processes related to inflammation, mitochondrial function, and antibacterial immunity, providing insights into potential therapeutic targets for sepsis and enhancing understanding of host-pathogen interactions.

References:
1. Song, Zichen, Meng, Leilei, He, Zhixiang, Liu, Anding, Fang, Haoshu. . LBP Protects Hepatocyte Mitochondrial Function Via the PPAR-CYP4A2 Signaling Pathway in a Rat Sepsis Model. In Shock (Augusta, Ga.), 56, 1066-1079. doi:10.1097/SHK.0000000000001808. https://pubmed.ncbi.nlm.nih.gov/33988537/
2. Schröder, Nicolas W J, Schumann, Ralf R. . Non-LPS targets and actions of LPS binding protein (LBP). In Journal of endotoxin research, 11, 237-42. doi:. https://pubmed.ncbi.nlm.nih.gov/16176661/
3. Bian, Ze-Chang, Cai, Xiao-Hui, Tan, Kian Ann, Kwan, Kit Yue, Xu, Peng. 2023. Identification and Functional Analysis of ToBPI1/LBP and ToBPI2/LBP in Anti-Bacterial Infection of Trachinotus ovatus. In Genes, 14, . doi:10.3390/genes14040826. https://pubmed.ncbi.nlm.nih.gov/37107584/
4. Kirschning, C, Unbehaun, A, Lamping, N, Herrmann, F, Schumann, R R. . Control of transcriptional activation of the lipopolysaccharide binding protein (LBP) gene by proinflammatory cytokines. In Cytokines, cellular & molecular therapy, 3, 59-62. doi:. https://pubmed.ncbi.nlm.nih.gov/9287245/
5. Wu, Ying, Du, Hehe, Zhu, Lin, Zhou, Yongcan, Sun, Yun. 2022. Bactericidal permeability-increasing protein/LPS-binding protein (BPI/LBP) enhances resistance of golden pompano Trachinotus ovatus against bacterial infection. In Fish & shellfish immunology, 131, 872-880. doi:10.1016/j.fsi.2022.10.065. https://pubmed.ncbi.nlm.nih.gov/36347416/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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