Bmp8b, short for Bone morphogenetic protein 8B, is a significant regulator in multiple biological processes. It is involved in pathways like SMAD2/3, NF-κB, and MAPK, and plays a role in energy homeostasis, adipocyte differentiation, and tumor progression [1,2]. It has been associated with the development and function of adipose tissue, and its study using genetic models can provide insights into its functions.

In animal models, Bmp8b -/- mice exhibit impaired thermogenesis, reduced metabolic rate, and weight gain despite hypophagia, indicating its crucial role in regulating energy balance through brown adipose tissue thermogenesis [3]. In non-alcoholic steatohepatitis (NASH), absence of BMP8B prevents hepatic stellate cell activation, reduces inflammation, and limits NASH progression [4]. In acute myeloid leukemia, knockdown of BMP8B inhibits cell proliferation, enhances apoptosis, and increases sensitivity to ATRA-induced cell differentiation [2].

In conclusion, Bmp8b is essential for regulating energy balance, adipocyte differentiation, and tumor progression. Gene knockout mouse models have been instrumental in revealing its role in conditions such as obesity-related energy imbalance, NASH, and acute myeloid leukemia, providing potential therapeutic targets for these diseases.