C57BL/6JCya-Il19em1flox/Cya
Common Name:
Il19-flox
Product ID:
S-CKO-18176
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Il19-flox
Strain ID
CKOCMP-329244-Il19-B6J-VA
Gene Name
Product ID
S-CKO-18176
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il19em1flox/Cya mice (Catalog S-CKO-18176) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112465
NCBI RefSeq
NM_001009940
Target Region
Exon 4~6
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Il19, an interleukin cytokine, is a member of the IL-10 family [1]. It plays diverse roles in maintaining tissue epithelial layer integrity and homeostasis, as well as in host defense mechanisms during infections [1]. The cytokine is involved in multiple pathways, such as those related to DNA damage-induced cytokine production [3].
In lung cancer, osteoclasts secrete Il19 which binds to Il-20RB on tumor cells, activating the JAK1/STAT3 signaling pathway and promoting bone metastasis [2]. In atopic dermatitis, a novel Il19+IGFL1+ keratinocyte subpopulation is increased in lesions, which may disrupt the skin barrier and mediate pruritus [4]. In chronic rhinosinusitis, Il19 is among the factors differentiating disease endotypes [6]. Polymorphisms in the Il19 gene are associated with immunological non-response in HIV-infected patients on cART [7]. Also, in systemic lupus erythematosus, the Il19 SNP rs2243188 is related to the disease pathogenesis [5].
In conclusion, Il19 has essential functions in maintaining tissue homeostasis and is involved in various disease processes including cancer metastasis, skin inflammation, sinusitis endotyping, and immunological response in HIV-infected patients, as well as in systemic lupus erythematosus. The study of Il19 using genetic models, like gene polymorphisms in these diseases, helps to understand its role in disease mechanisms, providing potential insights for treatment strategies.
References：
1. Ouyang, Wenjun, Rutz, Sascha, Crellin, Natasha K, Valdez, Patricia A, Hymowitz, Sarah G. . Regulation and functions of the IL-10 family of cytokines in inflammation and disease. In Annual review of immunology, 29, 71-109. doi:10.1146/annurev-immunol-031210-101312. https://pubmed.ncbi.nlm.nih.gov/21166540/
2. He, Yunfei, Luo, Wenqian, Liu, Yingjie, Yao, Feng, Hu, Guohong. 2022. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. In The Journal of clinical investigation, 132, . doi:10.1172/JCI157917. https://pubmed.ncbi.nlm.nih.gov/36006737/
3. Small, Sara H, Tang, E Jessica, Ragland, Ryan L, Johnson, F Bradley, Brown, Eric J. 2021. Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production. In Science signaling, 14, eaba2611. doi:10.1126/scisignal.aba2611. https://pubmed.ncbi.nlm.nih.gov/34932373/
4. Zhou, Jie, Liang, Gaopeng, Liu, Lu, Wang, Li, Song, Zhiqiang. 2023. Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis. In Journal of the European Academy of Dermatology and Venereology : JEADV, 37, 2336-2348. doi:10.1111/jdv.19256. https://pubmed.ncbi.nlm.nih.gov/37326015/
5. Wang, Weijie, Wang, Xinchang, Yang, Kepeng, Fan, Yongsheng. . Association of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus. In The Journal of international medical research, 49, 3000605211019187. doi:10.1177/03000605211019187. https://pubmed.ncbi.nlm.nih.gov/34044633/
6. Wang, Xiangdong, Sima, Yutong, Zhao, Yan, Zhang, Luo, Bachert, Claus. 2022. Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors. In The Journal of allergy and clinical immunology, 151, 458-468. doi:10.1016/j.jaci.2022.10.010. https://pubmed.ncbi.nlm.nih.gov/36272582/
7. García, Marcial, Jiménez-Sousa, María A, Blanco, Julià, Benito, José M, Rallón, Norma. 2019. CD4 recovery is associated with genetic variation in IFNγ and IL19 genes. In Antiviral research, 170, 104577. doi:10.1016/j.antiviral.2019.104577. https://pubmed.ncbi.nlm.nih.gov/31386862/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen