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C57BL/6JCya-Ubxn4em1flox/Cya
Common Name:
Ubxn4-flox
Product ID:
S-CKO-18505
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ubxn4-flox
Strain ID
CKOCMP-67812-Ubxn4-B6J-VB
Gene Name
Ubxn4
Product ID
S-CKO-18505
Gene Alias
1300013G12Rik; Ubxd2; mKIAA0242
Background
C57BL/6JCya
NCBI ID
67812
Modification
Conditional knockout
Chromosome
1
Phenotype
MGI:1915062
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ubxn4em1flox/Cya mice (Catalog S-CKO-18505) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027592
NCBI RefSeq
NM_026390
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ubxn4, a gene with no commonly mentioned aliases, has been implicated in multiple biological functions. It may be involved in cholesterol metabolism, as suggested by studies exploring the shared genetic mechanisms between obesity and metabolic disorders [2]. Additionally, it has roles related to the ubiquitin-proteasome system, interacting with proteins like ATAD1 in muscle to promote the degradation of desmin intermediate filaments [3]. It also appears to be part of the machinery regulating the ubiquitylation and ER-associated degradation of the WNT secretory factor EVI/WLS [4].

In the context of diseases, in non-small cell lung carcinoma, Ubxn4 was identified as a potential prognostic marker through RNA-sequencing of macrophages isolated from different regions of lung tumors. Its expression pattern was associated with the density and distribution of tumor-associated macrophages, which in turn were linked to patient survival [1]. In patients with severe haemophilia A, certain genetic variants in neighboring genes may affect the expression of Ubxn4, although the association with inhibitor development could not be confirmed with certainty due to limited sample size and high false-discovery rate [5].

In conclusion, Ubxn4 is involved in multiple biological processes, including lipid-related metabolism and protein degradation pathways. Its potential role as a prognostic marker in lung cancer and its possible connection to haemophilia A inhibitor development, as indicated by the studies, highlight its importance in disease-related research. The findings from these studies contribute to our understanding of the gene's functions in disease-associated biological processes.

References:
1. Zheng, Xiang, Weigert, Andreas, Reu, Simone, Winter, Hauke, Savai, Rajkumar. 2020. Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma. In Cancer research, 80, 4414-4425. doi:10.1158/0008-5472.CAN-20-0069. https://pubmed.ncbi.nlm.nih.gov/32699134/
2. Fu, Liwan, Han, Xiaodi, Wang, Yuquan, Hu, Yue-Qing. 2025. Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights. In Free radical biology & medicine, 231, 80-93. doi:10.1016/j.freeradbiomed.2025.02.033. https://pubmed.ncbi.nlm.nih.gov/39999931/
3. Aweida, Dina, Cohen, Shenhav. 2022. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. In EMBO reports, 23, e55175. doi:10.15252/embr.202255175. https://pubmed.ncbi.nlm.nih.gov/36278411/
4. Wolf, Lucie M, Lambert, Annika M, Haenlin, Julie, Boutros, Michael. 2021. EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2. In Journal of cell science, 134, . doi:10.1242/jcs.257790. https://pubmed.ncbi.nlm.nih.gov/34406391/
5. Spena, Silvia, Cairo, Andrea, Pappalardo, Emanuela, Gualtierotti, Roberta, Peyvandi, Flora. 2022. Genetic variants at the chromosomal region 2q21.3 underlying inhibitor development in patients with severe haemophilia A. In Haemophilia : the official journal of the World Federation of Hemophilia, 28, 270-277. doi:10.1111/hae.14503. https://pubmed.ncbi.nlm.nih.gov/35182444/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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