C57BL/6JCya-Setbp1em1flox/Cya
Common Name:
Setbp1-flox
Product ID:
S-CKO-18561
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Setbp1-flox
Strain ID
CKOCMP-240427-Setbp1-B6J-VA
Gene Name
Product ID
S-CKO-18561
Gene Alias
C130092E12; Seb; mKIAA0437
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Setbp1em1flox/Cya mice (Catalog S-CKO-18561) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025430
NCBI RefSeq
NM_053099
Target Region
Exon 4
Size of Effective Region
~4.2 kb
Detailed Document
Overview of Gene Research
SETBP1, also known as SET-binding protein 1/SEB/MRD29, is a SET-binding protein that regulates self-renewal potential through HOXA-protein activation [2]. It has significance in both neurological and cancer-related biological processes [1].
In myeloid neoplasms, mouse models have been crucial. For example, a mouse model expressing mutated SETBP1 in hematopoietic tissue showed profound alterations in the differentiation program of hematopoietic progenitors and developed a myeloid neoplasm with megakaryocytic dysplasia, splenomegaly, and bone marrow fibrosis [4]. Also, a Vav1-iCre;Setbp1fl/fl murine model indicated that SETBP1 depletion in normal hematopoiesis minimally alters self-renewal, differentiation, or reconstitution in vivo, and SETBP1 is dispensable for the development or maintenance of AML [3].
In conclusion, SETBP1 is important in regulating self-renewal potential via the HOXA-protein activation pathway. Mouse models, such as those with SETBP1 mutations or depletion, have revealed its role in myeloid neoplasms, showing its impact on hematopoietic progenitor differentiation and myeloid neoplasm development, as well as its dispensability in normal and malignant hematopoiesis.
References：
1. Kohyanagi, Naoki, Ohama, Takashi. 2023. The impact of SETBP1 mutations in neurological diseases and cancer. In Genes to cells : devoted to molecular & cellular mechanisms, 28, 629-641. doi:10.1111/gtc.13057. https://pubmed.ncbi.nlm.nih.gov/37489294/
2. Makishima, Hideki. 2017. Somatic SETBP1 mutations in myeloid neoplasms. In International journal of hematology, 105, 732-742. doi:10.1007/s12185-017-2241-1. https://pubmed.ncbi.nlm.nih.gov/28447248/
3. Tanaka, Atsushi, Nishimura, Koutarou, Saika, Wataru, Ogawa, Seishi, Inoue, Daichi. 2023. SETBP1 is dispensable for normal and malignant hematopoiesis. In Leukemia, 37, 1802-1811. doi:10.1038/s41375-023-01970-5. https://pubmed.ncbi.nlm.nih.gov/37464069/
4. Crespiatico, Ilaria, Zaghi, Mattia, Mastini, Cristina, Mologni, Luca, Piazza, Rocco. . First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis. In Blood, 143, 1399-1413. doi:10.1182/blood.2023021349. https://pubmed.ncbi.nlm.nih.gov/38194688/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen