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C57BL/6JCya-Cry2em1/Cya
Common Name:
Cry2-KO
Product ID:
S-KO-01639
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Cry2-KO
Strain ID
KOCMP-12953-Cry2-B6J-VA
Gene Name
Cry2
Product ID
S-KO-01639
Gene Alias
D130054K12Rik
Background
C57BL/6JCya
NCBI ID
12953
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:1270859
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cry2em1/Cya mice (Catalog S-KO-01639) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000090559
NCBI RefSeq
NM_009963
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cry2, or Cryptochrome 2, is a gene with diverse functions. In plants, it serves as a blue-light photoreceptor regulating various growth aspects. In mammals, it is a core circadian clock regulator and is also involved in processes like DNA damage repair. It participates in multiple pathways, such as those related to plant growth, adipogenesis, and circadian rhythm regulation, and is of great biological importance [1-10].

In plants, Arabidopsis studies show that Cry2 affects the transcriptome even in darkness, suppressing cell division in the root apical meristem to inhibit root elongation in the dark, while blue-light oligomerizes Cry2 to de-repress root elongation. It physically interacts with FORKED-LIKE 1 (FL1) and FL3 in darkness to inhibit their pro-growth activity on cell division genes [1]. In Arabidopsis, Cry2 is also involved in blue-light-dependent cold acclimation through the CRY2-COP1-HY5-BBX7/8 module, and in thermosensory flowering via interaction with CIS1 to regulate FLM alternative splicing [2,4].

In mammals, in vitro and in vivo studies on adipogenesis demonstrate that Cry2 promotes adipocyte development by repressing the Wnt pathway through interaction with Per2. Mutations in Cry2 in mouse models can accelerate the growth of primary mouse fibroblasts expressing high levels of c-MYC and suppress P53 target-gene expression [5-7]. In 5xFAD mice, overexpression of Cry2 leads to decreased cognitive function, while down-regulation attenuates sleep-deprivation-induced cognitive decline, as Cry2 reduces CISH-mediated STAT1 phosphorylation resulting in synaptic dysfunction [3].

In conclusion, Cry2 plays essential roles in plant growth, including root elongation, cold acclimation, and thermosensory flowering. In mammals, it is involved in adipogenesis, cell growth regulation, and cognitive function related to sleep deprivation. The use of genetic models, such as Arabidopsis in plant studies and mouse models in mammalian research, has significantly contributed to understanding Cry2's functions in these biological processes and disease-related conditions.

References:

1. Zeng, Desheng, Lv, Junqing, Li, Xu, Liu, Hongtao. 2024. The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth. In Cell, 188, 60-76.e20. doi:10.1016/j.cell.2024.10.031. https://pubmed.ncbi.nlm.nih.gov/39549699/

2. Li, Youping, Shi, Yiting, Li, Minze, Liu, Hongtao, Yang, Shuhua. . The CRY2-COP1-HY5-BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis. In The Plant cell, 33, 3555-3573. doi:10.1093/plcell/koab215. https://pubmed.ncbi.nlm.nih.gov/34427646/

3. Luo, Sumei, Guo, Lizhe, Chen, Na, Wang, Yunjiao, Wang, E. 2024. CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice. In PloS one, 19, e0306930. doi:10.1371/journal.pone.0306930. https://pubmed.ncbi.nlm.nih.gov/39012854/

4. Zhao, Zhiwei, Dent, Craig, Liang, Huafeng, Balasubramanian, Sureshkumar, Liu, Hongtao. 2022. CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing. In Nature communications, 13, 7045. doi:10.1038/s41467-022-34886-2. https://pubmed.ncbi.nlm.nih.gov/36396657/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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