C57BL/6NCya-Il15raem1/Cya
Common Name
Il15ra-KO
Product ID
S-KO-02625
Backgroud
C57BL/6NCya
Strain ID
KOCMP-16169-Il15ra-B6N-VA
Status
When using this mouse strain in a publication, please cite “Il15ra-KO Mouse (Catalog S-KO-02625) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Il15ra-KO
Strain ID
KOCMP-16169-Il15ra-B6N-VA
Gene Name
Product ID
S-KO-02625
Gene Alias
IL-15RA
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000078834
NCBI RefSeq
NM_008358
Target Region
Exon 2
Size of Effective Region
~0.2 kb
Overview of Gene Research
Il15ra, encoding interleukin-15 receptor alpha, is a crucial component of interleukin-15 (IL15) pro-inflammatory signaling. IL15/IL15RA signaling is involved in various physiological functions. It usually forms a heterotrimer with IL2 receptors IL2RB and IL2RG to regulate the proliferation and differentiation of cytotoxic T cells and NK cells [2]. In addition, it also impacts functions like muscle contractility, overall metabolism, and is present in the circulation and detected in multiple tissues [1].
In an Il15ra whole-body knockout mouse (Il15ra-/-) study, lack of IL15RA decreased bone mineralization in vivo and in isolated primary osteogenic cultures, suggesting a cell-autonomous effect. The Il15ra-/-osteogenic cultures also had a reduced Rankl/Opg mRNA ratio, indicating defective osteoblast/osteoclast coupling. Transcriptome analysis of primary pre-osteoblasts from normal and Il15ra-/-mice identified differentially expressed genes related to metabolism, immune response, bone mineralization, and morphogenesis [1].
In conclusion, Il15ra is essential for multiple biological functions. The Il15ra knockout mouse model has revealed its cell-autonomous role in osteoblast function and bone mineralization, providing insights into the role of IL15RA in skeletal system development and function [1].
References:
1. Loro, Emanuele, Ramaswamy, Girish, Chandra, Abhishek, Shore, Eileen M, Khurana, Tejvir S. 2017. IL15RA is required for osteoblast function and bone mineralization. In Bone, 103, 20-30. doi:10.1016/j.bone.2017.06.003. https://pubmed.ncbi.nlm.nih.gov/28602725/
2. Marra, Pierfrancesco, Mathew, Sumi, Grigoriadis, Anita, Hayday, Adrian, Tutt, Andrew. 2014. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. In Cancer research, 74, 4908-21. doi:10.1158/0008-5472.CAN-14-0637. https://pubmed.ncbi.nlm.nih.gov/24980552/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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