C57BL/6NCya-Cnmdem1/Cya
Common Name
Cnmd-KO
Product ID
S-KO-02874
Backgroud
C57BL/6NCya
Strain ID
KOCMP-16840-Cnmd-B6N-VA
When using this mouse strain in a publication, please cite “Cnmd-KO Mouse (Catalog S-KO-02874) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cnmd-KO
Strain ID
KOCMP-16840-Cnmd-B6N-VA
Gene Name
Product ID
S-KO-02874
Gene Alias
Bricd3, ChM-I, Chmd, Lect1
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022603
NCBI RefSeq
NM_010701
Target Region
Exon 4~5
Size of Effective Region
~5.1 kb
Overview of Gene Research
Chondromodulin-I (Cnmd), also known as Chm-1, Chm-I, or Lect1, is a type II transmembrane glycoprotein-encoding gene. It is primarily expressed in cartilage and healthy cardiac valves. Cnmd plays a vital role in chondrocyte proliferation, cartilage homeostasis, and angiogenesis blocking, which are essential for endochondral ossification and tissue development, homeostasis, repair, and regeneration [1,3].
In Cnmd null (Cnmd -/-) mice, less cartilage callus was observed during distraction osteogenesis, and the distraction gap was filled by fibrous tissues. Radiological and histological investigations demonstrated delayed bone consolidation and remodeling of the lengthened segment. Eventually, Cnmd deficiency caused a one-week delay in the peak expression of VEGF, MMP2, and MMP9 genes, as well as subsequent angiogenesis and osteoclastogenesis, indicating that Cnmd is necessary for cartilage callus distraction [2].
In conclusion, Cnmd is crucial for cartilage-related biological processes, especially in cartilage callus distraction as revealed by Cnmd KO mouse models. Its role in regulating angiogenesis and chondrocyte-related functions may have implications for understanding and treating diseases such as osteoarthritis, where its down-regulation correlates with disease severity [1,2,3].
References:
1. Reyes Alcaraz, Viviana, Pattappa, Girish, Miura, Shigenori, Shukunami, Chisa, Docheva, Denitsa. 2024. A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue. In International journal of molecular sciences, 25, . doi:10.3390/ijms25115839. https://pubmed.ncbi.nlm.nih.gov/38892027/
2. Yukata, Kiminori, Shukunami, Chisa, Matsui, Yoshito, Hiraki, Yuji, Yasui, Natsuo. 2023. Chondromodulin is necessary for cartilage callus distraction in mice. In PloS one, 18, e0280634. doi:10.1371/journal.pone.0280634. https://pubmed.ncbi.nlm.nih.gov/36795722/
3. Zhu, Sipin, Qiu, Heng, Bennett, Samuel, Xu, Huazi, Xu, Jiake. 2019. Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease. In Cellular and molecular life sciences : CMLS, 76, 4493-4502. doi:10.1007/s00018-019-03225-y. https://pubmed.ncbi.nlm.nih.gov/31317206/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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