C57BL/6JCya-Scn10aem1/Cya
Common Name
Scn10a-KO
Product ID
S-KO-04208
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20264-Scn10a-B6J-VA
Status
When using this mouse strain in a publication, please cite “Scn10a-KO Mouse (Catalog S-KO-04208) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Scn10a-KO
Strain ID
KOCMP-20264-Scn10a-B6J-VA
Gene Name
Product ID
S-KO-04208
Gene Alias
PN3, SNS, Nav1.8
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000084787
NCBI RefSeq
NM_001205321
Target Region
Exon 3~6
Size of Effective Region
~21.2 kb
Overview of Gene Research
Scn10a, encoding the neuronal voltage-gated sodium channel NaV1.8, is associated with multiple physiological and pathological processes. It plays a role in cardiac electrophysiology, pain perception, and is also linked to various diseases. Genetic models, especially KO/CKO mouse models, are valuable for studying its functions [1,2].
In mouse models, disruption of the intronic enhancer of Scn10a led to reduced cardiac Scn10a-short expression, decreased cardiac sodium current in atrial cardiomyocytes, atrial conduction slowing, and arrhythmia. The Scn10a-short transcript, expressed in cardiomyocytes of the atria, sinoatrial node, and ventricular conduction system, impacts NaV1.5-mediated sodium current and heart rhythm. Complete loss-of-function or knockout (KO) of Scn10a in rodent models decreased sensitivity to various pain stimuli [1,2].
In conclusion, Scn10a is crucial for cardiac conduction and pain perception. Mouse KO models have revealed its role in cardiac arrhythmias and pain-related pathophysiological mechanisms. Understanding Scn10a's functions provides insights into related diseases, such as atrial fibrillation, Brugada syndrome, and pain-related disorders [1,2,3].
References:
1. Man, Joyce C K, Bosada, Fernanda M, Scholman, Koen T, Barnett, Phil, Christoffels, Vincent M. 2021. Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction. In Circulation, 144, 229-242. doi:10.1161/CIRCULATIONAHA.121.054083. https://pubmed.ncbi.nlm.nih.gov/33910361/
2. Xue, Yaping, Chidiac, Celeste, Herault, Yann, Gaveriaux-Ruff, Claire. 2021. Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models. In Neuroscience letters, 753, 135844. doi:10.1016/j.neulet.2021.135844. https://pubmed.ncbi.nlm.nih.gov/33775738/
3. Huang, Yan, Chen, Xiao-Meng, Barajas-Martinez, Hector, Antzelevitch, Charles, Hu, Dan. . Common variants in SCN10A gene associated with Brugada syndrome. In Human molecular genetics, 31, 157-165. doi:10.1093/hmg/ddab217. https://pubmed.ncbi.nlm.nih.gov/34312669/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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