C57BL/6JCya-Tmem82em1/Cya
Common Name:
Tmem82-KO
Product ID:
S-KO-04979
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tmem82-KO
Strain ID
KOCMP-213989-Tmem82-B6J-VA
Gene Name
Product ID
S-KO-04979
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmem82em1/Cya mice (Catalog S-KO-04979) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053263
NCBI RefSeq
NM_145987
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
TMEM82, whose full name is Transmembrane Protein 82, has its role yet to be comprehensively defined in terms of its essential function, associated pathways, and overall biological importance. However, genetic models could potentially be valuable in further exploring its functions [1,2].
In a study on hepatocellular carcinoma, TMEM82 was identified as one of the novel differentially-expressed protein-coding genes lacking documented expression profiles in liver cancer, suggesting its possible role in the pathology of hepatocellular carcinoma [1].
In another study related to colorectal cancer, the expression level of TMEM82 was found not to be correlated with the overall survival of patients with CRC, indicating its potential non-involvement in CRC patient survival prognosis [2].
In conclusion, TMEM82 shows potential associations with diseases such as hepatocellular carcinoma and colorectal cancer. In hepatocellular carcinoma, its differential expression implies a possible role in the disease's pathology, while in colorectal cancer, its lack of correlation with patient survival provides insights into its limited role in this aspect. Further research using gene knockout or conditional knockout mouse models could help to more precisely define its biological functions and contributions to these disease areas.
References:
1. Lin, K-T, Shann, Y-J, Chau, G-Y, Hsu, C-N, Huang, C-Y F. 2013. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. In Oncogene, 33, 4786-94. doi:10.1038/onc.2013.424. https://pubmed.ncbi.nlm.nih.gov/24141781/
2. Guo, Shuai, Sun, Yang. 2022. OTOP2, Inversely Modulated by miR-3148, Inhibits CRC Cell Migration, Proliferation and Epithelial-Mesenchymal Transition: Evidence from Bioinformatics Data Mining and Experimental Verification. In Cancer management and research, 14, 1371-1384. doi:10.2147/CMAR.S345299. https://pubmed.ncbi.nlm.nih.gov/35418782/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen