Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Ucp1em1/Cya
Common Name:
Ucp1-KO
Product ID:
S-KO-05629
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ucp1-KO
Strain ID
KOCMP-22227-Ucp1-B6J-VA
Gene Name
Ucp1
Product ID
S-KO-05629
Gene Alias
Slc25a7; Ucp
Background
C57BL/6JCya
NCBI ID
22227
Modification
Conventional knockout
Chromosome
8
Phenotype
MGI:98894
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ucp1em1/Cya mice (Catalog S-KO-05629) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034146
NCBI RefSeq
NM_009463
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ucp1, short for uncoupling protein 1, is a key effector in thermogenic adipocytes. It dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient from mitochondrial respiration, playing a central role in BAT thermogenesis and systemic energy homeostasis [1]. This process is crucial for mammals to combat hypothermia and metabolic dysregulation [3]. Genetic models, such as gene knockout mice, have been essential in studying Ucp1.

Germline Ucp1 -/- mice have been used to infer Ucp1's role as the sole mediator of adipocyte thermogenesis. However, these mice also have secondary changes in brown adipose tissue. To mitigate such confounding factors, inducible adipocyte-selective Ucp1 disruption mice were constructed. It was found that while germline Ucp1 -/- mice succumb to cold-induced hypothermia, most inducible Ucp1-deleted mice maintain homeothermy in the cold. But co-deletion of Ucp1 and creatine kinase b (Ckb) exacerbates cold intolerance. This suggests that thermogenic adipocytes use non-paralogous protein redundancy through Ucp1 and Ckb for cold-induced energy dissipation [2].

In conclusion, Ucp1 is essential for thermogenesis in adipocytes, regulating energy dissipation and maintaining body temperature. The use of Ucp1 KO and inducible Ucp1-deleted mouse models has revealed not only Ucp1's crucial role in thermogenesis but also its interaction with other proteins like Ckb. These findings contribute to understanding metabolic diseases related to thermogenic dysfunction, offering potential therapeutic targets for conditions such as obesity and type 2 diabetes [1,2].

References:

1. Ikeda, Kenji, Yamada, Tetsuya. 2020. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes. In Frontiers in endocrinology, 11, 498. doi:10.3389/fendo.2020.00498. https://pubmed.ncbi.nlm.nih.gov/32849287/

2. Rahbani, Janane F, Bunk, Jakub, Lagarde, Damien, Koza, Robert A, Kazak, Lawrence. 2024. Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB. In Cell metabolism, 36, 526-540.e7. doi:10.1016/j.cmet.2024.01.001. https://pubmed.ncbi.nlm.nih.gov/38272036/

3. Xue, Kaili, Wu, Dongmei, Wang, Yushuang, Wang, Zihao, Qiu, Yifu. 2022. The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis. In Cell metabolism, 34, 1325-1341.e6. doi:10.1016/j.cmet.2022.07.011. https://pubmed.ncbi.nlm.nih.gov/35977541/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest