Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Vwfem1/Cya
Common Name:
Vwf-KO
Product ID:
S-KO-05729
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Vwf-KO
Strain ID
KOCMP-22371-Vwf-B6J-VA
Gene Name
Vwf
Product ID
S-KO-05729
Gene Alias
6820430P06Rik; B130011O06Rik; C630030D09; F8VWF; VWD
Background
C57BL/6JCya
NCBI ID
22371
Modification
Conventional knockout
Chromosome
6
Phenotype
MGI:98941
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vwfem1/Cya mice (Catalog S-KO-05729) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112254
NCBI RefSeq
NM_011708
Target Region
Exon 6
Size of Effective Region
~1.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Von Willebrand factor (VWF), encoded by the Vwf gene, is a large adhesive multimeric glycoprotein crucial for hemostasis. It plays an essential role in regulating the balance between blood clotting and bleeding, acting as a bridge between platelets and the subendothelial matrix after vessel damage [3,4,6]. Aberrant VWF regulation can lead to a spectrum of diseases from bleeding disorders like von Willebrand disease (VWD) to thrombotic thrombocytopenic purpura (TTP) [4].

Regarding low VWF levels, international guidelines suggest diagnosing low VWF when plasma VWF antigen (VWF:Ag) levels are in the range of 30-50 IU/dL. However, its pathogenesis remains poorly understood, causing challenges in genetic counseling, diagnosis, and management. Some studies indicate that the number of rare nonsynonymous VWF variants significantly predicts VWF:Ag levels, and enhanced VWF clearance may contribute to the pathobiology of low VWF, but the VWF propeptide (VWFpp)-to-VWF antigen (VWF:Ag) ratio may have limitations in reflecting this [1,2,5]. Also, in children undergoing tonsillectomy, low VWF levels do not seem to correlate with bleeding [7]. In COVID-19, increased VWF levels and an altered VWF/ADAMTS-13 axis may promote (micro)thrombosis [3]. Additionally, higher plasma VWF:Ag levels in acute myocardial infarction patients are associated with long-term major adverse cardiopulmonary and cerebrovascular events (MACEs) [6].

In conclusion, Vwf is vital for maintaining hemostasis. Research on Vwf, including through studies related to low VWF levels, its variants, and its role in diseases like COVID-19 and acute myocardial infarction, helps in understanding the molecular mechanisms underlying bleeding and thrombotic disorders. This knowledge can potentially guide better diagnosis, genetic counseling, and treatment strategies for related diseases [1-7].

References:

1. O'Donnell, James S. . Low VWF: insights into pathogenesis, diagnosis, and clinical management. In Blood advances, 4, 3191-3199. doi:10.1182/bloodadvances.2020002038. https://pubmed.ncbi.nlm.nih.gov/32663299/

2. Sadler, Brooke, Christopherson, Pamela A, Haller, Gabe, Montgomery, Robert R, Di Paola, Jorge. . von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene. In Blood, 137, 3277-3283. doi:10.1182/blood.2020009999. https://pubmed.ncbi.nlm.nih.gov/33556167/

3. Favaloro, Emmanuel J, Henry, Brandon Michael, Lippi, Giuseppe. 2021. Increased VWF and Decreased ADAMTS-13 in COVID-19: Creating a Milieu for (Micro)Thrombosis. In Seminars in thrombosis and hemostasis, 47, 400-418. doi:10.1055/s-0041-1727282. https://pubmed.ncbi.nlm.nih.gov/33893632/

4. Xiang, Yaozu, Hwa, John. . Regulation of VWF expression, and secretion in health and disease. In Current opinion in hematology, 23, 288-93. doi:10.1097/MOH.0000000000000230. https://pubmed.ncbi.nlm.nih.gov/26771163/

5. Doherty, Dearbhla, Byrne, Mary, Nolan, Margaret, James, Paula D, O'Donnell, James S. . Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance. In Blood advances, 7, 302-308. doi:10.1182/bloodadvances.2022007340. https://pubmed.ncbi.nlm.nih.gov/35523118/

6. Xier, Zulipiyemu, Zhu, Yu-Xia, Tang, Shou-Wei, Huojia, Guzailinuer, Peng, Hui. 2023. Plasma VWF: Ag levels predict long-term clinical outcomes in patients with acute myocardial infarction. In Frontiers in cardiovascular medicine, 9, 1013815. doi:10.3389/fcvm.2022.1013815. https://pubmed.ncbi.nlm.nih.gov/36684571/

7. Gill, Joan Cox, Conley, Stephen F, Johnson, Victoria P, Montgomery, Robert R, Flood, Veronica H. . Low VWF levels in children and lack of association with bleeding in children undergoing tonsillectomy. In Blood advances, 4, 100-105. doi:10.1182/bloodadvances.2019000992. https://pubmed.ncbi.nlm.nih.gov/31905240/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest