Gpr152 is a member of the Rhodopsin family of human G-protein coupled receptors (GPCRs), which shows an evolutionary relationship to CRTH2/FPRs [1]. GPCRs are crucial in mediating various cellular responses to extracellular stimuli, participating in numerous physiological and pathological processes. Understanding Gpr152 through genetic models could potentially shed light on its specific functions within these pathways.

A single-nucleotide polymorphism (SNP) rs869736, along with nine other SNPs in nearly perfect linkage disequilibrium, spreads out for 26 kb on chromosome 11q13.1 covering Gpr152 among other genes. However, among these four genes, only PTPRCAP expression was affected by haplotypes of the 10 SNPs. The minor-allele T of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression, though it's not clear if Gpr152 is directly involved in this process [2].

In conclusion, Gpr152, as a GPCR, is likely involved in important cellular signaling pathways. While no direct functional study from gene knockout models is available in the provided references, the association with a genetic region related to diffuse-type gastric cancer susceptibility indicates its potential significance in this disease area, warranting further research to fully elucidate its biological functions and role in disease mechanisms.

References:

1. Gloriam, David E I, Schiöth, Helgi B, Fredriksson, Robert. . Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. In Biochimica et biophysica acta, 1722, 235-46. doi:. https://pubmed.ncbi.nlm.nih.gov/15777626/

2. Ju, Hyoungseok, Lim, Byungho, Kim, Minjin, Choi, Bo Youl, Kang, Changwon. . A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. In Neoplasia (New York, N.Y.), 11, 1340-7. doi:. https://pubmed.ncbi.nlm.nih.gov/20019842/