C57BL/6JCya-Avpr1aem1/Cya
Common Name:
Avpr1a-KO
Product ID:
S-KO-10470
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Avpr1a-KO
Strain ID
KOCMP-54140-Avpr1a-B6J-VA
Gene Name
Product ID
S-KO-10470
Gene Alias
AVPR; Avpr1; V1a; V1aR
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Avpr1aem1/Cya mice (Catalog S-KO-10470) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020323
NCBI RefSeq
NM_016847
Target Region
Exon 1~2
Size of Effective Region
~4.8 kb
Detailed Document
Overview of Gene Research
Avpr1a, the arginine vasopressin receptor 1A gene, encodes a receptor that interacts with the arginine vasopressin hormone. This interaction is involved in physiological stress regulation, blood pressure control, and child development. It also plays a role in maintaining homeostasis and regulating social behavior. The neuropeptide arginine vasopressin (AVP), which binds to AVPR1A, has significant functions in various biological processes [1,2].
In AVPR1A knockout (KO) postnatal day 0 (P0) male and female mice on a C57BL/6J background, specific AVPR1A ligand binding was significantly reduced or absent in control samples compared to wildtype mice. This indicates that AVPR1A has roles in modulating peripheral physiology and development in neonates. In female mice, loss of function studies demonstrated that AVPR1A signaling in the central nucleus of the amygdala (CeA) is required for the effects of chronic social isolation stress (CSIS) on anxiety-related behaviors, while it has no effect in males or group-housed females [2,3].
In conclusion, Avpr1a is crucial for multiple biological functions such as neonatal development and social behavior regulation. AVPR1A KO mouse models have revealed its role in anxiety-related behaviors in female mice, providing insights into potential therapeutic applications for females experiencing heightened susceptibility to anxiety disorders due to social isolation [2,3].
References:
1. Nidey, Nichole, Bowers, Katherine, Ding, Lili, Mahabee-Gittens, E Melinda, Folger, Alonzo T. 2023. Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking. In Toxics, 11, . doi:10.3390/toxics11100855. https://pubmed.ncbi.nlm.nih.gov/37888705/
2. Day, Katherine R, Coleman, Alexis, Greenwood, Maria A, Hammock, Elizabeth A D. 2020. AVPR1A distribution in the whole C57BL/6J mouse neonate. In Scientific reports, 10, 14512. doi:10.1038/s41598-020-71392-1. https://pubmed.ncbi.nlm.nih.gov/32884025/
3. François, Marie, Delgado, Isabella Canal, Lafond, Alexandre, Dölen, Gül, Zeltser, Lori M. 2023. Amygdala AVPR1A mediates susceptibility to chronic social isolation in females. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.02.15.528679. https://pubmed.ncbi.nlm.nih.gov/36824966/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen