C57BL/6NCya-Sec1em1/Cya
Common Name
Sec1-KO
Product ID
S-KO-10883
Backgroud
C57BL/6NCya
Strain ID
KOCMP-56546-Sec1-B6N-VA
Status
When using this mouse strain in a publication, please cite “Sec1-KO Mouse (Catalog S-KO-10883) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Sec1-KO
Strain ID
KOCMP-56546-Sec1-B6N-VA
Gene Name
Product ID
S-KO-10883
Gene Alias
Fut3, Fut10
Background
C57BL/6NCya
Gene Full Name
secretory blood group 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000040636
NCBI Transcript ID
NM_001271578
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Overview of Gene Research
Sec1, a member of the Sec1 family, is involved in synaptic transmission and general secretion [1]. It lacks a transmembrane domain but can be membrane-bound, potentially due to interaction with syntaxin. The Sec1 proteins play a positive role in exocytosis, and their loss-of-function mutations can block protein transport in yeast [1].
In a mouse model of inflammatory bowel disease (IBD), Sec1 knockout led to the deterioration of IBD and elevated immune responses in the colonic mucosa. Silencing Sec1 in murine colon cancer cell lines increased the secretion of inflammatory cytokines. Also, Sec1 expression promoted the proliferation of colon epithelial cells, inhibited cell apoptosis, and facilitated the repair of inflammatory injury [2]. In addition, Sec1 knockout mice had significant weight gain, abdominal fat accumulation, and changes in gut microbial flora abundance and metabolic function [3].
In conclusion, Sec1 plays important roles in regulating intestinal mucosal immunity in IBD and impacts gut microbiota-related physiological conditions. The gene knockout mouse models have revealed its functions in these biological processes and disease conditions, providing valuable insights into understanding the mechanisms underlying IBD and gut microbiota-related disorders.
References:
1. Halachmi, N, Lev, Z. . The Sec1 family: a novel family of proteins involved in synaptic transmission and general secretion. In Journal of neurochemistry, 66, 889-97. doi:. https://pubmed.ncbi.nlm.nih.gov/8769846/
2. Cai, Jing, Wu, Hao, Wang, Chenxing, Jin, Yingli, Qian, Cao. 2023. Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. In BMC immunology, 24, 51. doi:10.1186/s12865-023-00578-9. https://pubmed.ncbi.nlm.nih.gov/38066482/
3. Ren, Zhanshi, Fan, Hairui, Gu, Shanshen, Bao, Wenbin, Wu, Shenglong. 2022. Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota. In Genes, 13, . doi:10.3390/genes13101858. https://pubmed.ncbi.nlm.nih.gov/36292744/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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