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C57BL/6JCya-Rbms1em1/Cya
Common Name:
Rbms1-KO
Product ID:
S-KO-10971
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rbms1-KO
Strain ID
KOCMP-56878-Rbms1-B6J-VA
Gene Name
Rbms1
Product ID
S-KO-10971
Gene Alias
2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1
Background
C57BL/6JCya
NCBI ID
56878
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:1861774
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbms1em1/Cya mice (Catalog S-KO-10971) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028347
NCBI RefSeq
NM_020296
Target Region
Exon 3
Size of Effective Region
~0.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
RBMS1, the RNA-binding motif single-strand interacting protein 1, is an important RNA-binding protein. It participates in regulating various biological processes through post-transcriptional regulation, such as influencing mRNA stability and translation [7,8]. It is associated with multiple pathways and is of great biological significance in processes like cell proliferation, apoptosis, and ferroptosis. Genetic models, including gene knockout (KO) or conditional knockout (CKO) mouse models, are valuable tools to study its functions.

In cancer research, RBMS1 shows diverse roles. In lung cancer, RBMS1 depletion inhibits tumor progression both in vivo and in vitro by promoting ferroptosis through inhibiting SLC7A11 translation [1]. In gastric cancer, its overexpression promotes metastasis via the autocrine IL-6/JAK2/STAT3 signaling pathway [2]. In non-small cell lung cancer (NSCLC), RBMS1 interacts with YTHDF1 to promote S100P translation and accelerate metastasis, and its ablation suppresses metastasis [3]. In triple-negative breast cancer, RBMS1 ablation promotes anti-tumor immunity by down-regulating PD-L1 [4]. In ocular melanoma, silencing RBMS1 inhibits cell proliferation and promotes apoptosis [5]. In glioblastoma, interfering with RBMS1 inhibits malignant progression and promotes ferroptosis [6]. In colorectal cancer, inhibiting RBMS1 restores oxaliplatin sensitivity by causing ferroptosis [9]. However, in colon cancer, RBMS1 functions as a suppressor of metastasis through targeted stabilization of its mRNA regulon, and its silencing increases metastatic capacity in xenograft mouse models [8].

In conclusion, RBMS1 is a crucial post-transcriptional regulator involved in multiple biological processes. Studies using KO or CKO mouse models have revealed its significant roles in various cancer-related processes, such as tumor progression, metastasis, ferroptosis, and anti-tumor immunity. Understanding RBMS1's functions provides potential therapeutic targets for treating cancers.

References:

1. Zhang, Wenjing, Sun, Yu, Bai, Lu, Liu, Han, Wang, Yang. . RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. In The Journal of clinical investigation, 131, . doi:10.1172/JCI152067. https://pubmed.ncbi.nlm.nih.gov/34609966/

2. Liu, Mengyuan, Li, Heming, Zhang, Huijing, Xue, Lei, Xu, Lu. 2022. RBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling. In Cell death & disease, 13, 287. doi:10.1038/s41419-022-04747-3. https://pubmed.ncbi.nlm.nih.gov/35361764/

3. Sun, Yu, Chen, Dan, Sun, Siwen, Wang, Yang, Zhang, Wenjing. 2024. RBMS1 Coordinates with the m6A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2307122. doi:10.1002/advs.202307122. https://pubmed.ncbi.nlm.nih.gov/38342601/

4. Zhang, Jinrui, Zhang, Ge, Zhang, Wenjing, Liu, Han, Wang, Yang. 2022. Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer. In Cell death and differentiation, 29, 2247-2261. doi:10.1038/s41418-022-01012-0. https://pubmed.ncbi.nlm.nih.gov/35538152/

5. Yang, Ludi, Wang, Gaoming, Tian, Hao, Cui, Ran, Zhuang, Ai. 2024. RBMS1 reflects a distinct microenvironment and promotes tumor progression in ocular melanoma. In Experimental eye research, 246, 109990. doi:10.1016/j.exer.2024.109990. https://pubmed.ncbi.nlm.nih.gov/38969283/

6. Liang, Xiaosong, Wang, Gang, Xue, Chunxiao, Zhou, Yifu. 2024. RBMS1 interference inhibits malignant progression of glioblastoma cells and promotes ferroptosis. In Discover oncology, 15, 548. doi:10.1007/s12672-024-01430-1. https://pubmed.ncbi.nlm.nih.gov/39392522/

7. Shin, Chang Hoon, Rossi, Martina, Anerillas, Carlos, Abdelmohsen, Kotb, Gorospe, Myriam. 2024. Increased ANKRD1 Levels in Early Senescence Mediated by RBMS1-Elicited ANKRD1 mRNA Stabilization. In Molecular and cellular biology, 44, 194-208. doi:10.1080/10985549.2024.2350540. https://pubmed.ncbi.nlm.nih.gov/38769646/

8. Yu, Johnny, Navickas, Albertas, Asgharian, Hosseinali, Mardakheh, Faraz K, Goodarzi, Hani. 2020. RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon. In Cancer discovery, 10, 1410-1423. doi:10.1158/2159-8290.CD-19-1375. https://pubmed.ncbi.nlm.nih.gov/32513775/

9. Xu, Yini, Hao, Jingpeng, Chen, Qiang, Zhang, Jingyi, Wang, Hao. 2023. Inhibition of the RBMS1/PRNP axis improves ferroptosis resistance-mediated oxaliplatin chemoresistance in colorectal cancer. In Molecular carcinogenesis, 63, 224-237. doi:10.1002/mc.23647. https://pubmed.ncbi.nlm.nih.gov/37861356/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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