C57BL/6JCya-CK137956em1/Cya
Common Name
CK137956-KO
Product ID
S-KO-11354
Backgroud
C57BL/6JCya
Strain ID
KOCMP-635169-CK137956-B6J-VA
Status
When using this mouse strain in a publication, please cite “CK137956-KO Mouse (Catalog S-KO-11354) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
CK137956-KO
Strain ID
KOCMP-635169-CK137956-B6J-VA
Gene Name
Product ID
S-KO-11354
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000030614
NCBI RefSeq
NM_001134733
Target Region
Exon 2~4
Size of Effective Region
~7.7 kb
Overview of Gene Research
Ck137956, also named Tssa (testis-specific and spermiogenic arrest protein), is essential for male fertility. It is involved in the post-transcriptional regulation pathway during spermiogenesis. Spermiogenesis is a complex process where sperm is formed through chromatin condensation and cessation of transcription, and Ck137956/Tssa has a crucial role in this biological process [1].
Deletion of Tssa in mouse models (KO mouse model) led to male sterility and absence of sperm formation. Spermiogenesis arrested at the round spermatid stage, and numerous spermiogenic mRNAs were down-regulated. Also, the deletion disrupted the localization of Miwi to the chromatoid body. Tssa interacted with Miwi in repressed mRNPs and stabilized Miwi-interacting spermiogenesis-essential mRNAs [1].
In conclusion, Ck137956/Tssa is indispensable in male fertility. The gene knockout mouse models have revealed its critical role in post-transcriptional regulations during spermiogenesis, contributing to our understanding of male infertility mechanisms [1].
References:
1. Chen, Yu, Zhang, Xiangzheng, Jiang, Jiayin, Cui, Yiqiang, Guo, Xuejiang. 2023. Regulation of Miwi-mediated mRNA stabilization by Ck137956/Tssa is essential for male fertility. In BMC biology, 21, 89. doi:10.1186/s12915-023-01589-z. https://pubmed.ncbi.nlm.nih.gov/37069605/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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