C57BL/6JCya-4933411K16Rikem1/Cya
Common Name
4933411K16Rik-KO
Product ID
S-KO-11902
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66765-4933411K16Rik-B6J-VA
When using this mouse strain in a publication, please cite “4933411K16Rik-KO Mouse (Catalog S-KO-11902) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
4933411K16Rik-KO
Strain ID
KOCMP-66765-4933411K16Rik-B6J-VA
Gene Name
Product ID
S-KO-11902
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000164518
NCBI RefSeq
NM_025752
Target Region
Exon 1
Size of Effective Region
~1.2 kb
Overview of Gene Research
4933411K16Rik is one of the genes enriched in male reproductive tissues. However, prior to relevant research, its exact function, associated pathways, and overall biological importance remained largely unknown. Genetic models like the KO mouse model can be valuable tools for exploring its function [1].
In a study, a gene-deficient mouse model for 4933411K16Rik was established using the CRISPR/Cas9 system. Surprisingly, the 4933411K16Rik-deficient mice exhibited normal fertility in natural breeding experiments. This indicates that 4933411K16Rik is not essential for male fertility [1].
In conclusion, through the KO mouse model-based research, it was revealed that 4933411K16Rik is dispensable for male fertility. This finding contributes to a more efficient allocation of research resources in the exploration of male reproductive biology, preventing unnecessary duplication of efforts in generating knockout mice for genes without an apparent male-fertility-related phenotype [1].
References:
1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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