4933411K16Rik is one of the genes enriched in male reproductive tissues. However, prior to relevant research, its exact function, associated pathways, and overall biological importance remained largely unknown. Genetic models like the KO mouse model can be valuable tools for exploring its function [1].

In a study, a gene-deficient mouse model for 4933411K16Rik was established using the Nuclease technology system. Surprisingly, the 4933411K16Rik-deficient mice exhibited normal fertility in natural breeding experiments. This indicates that 4933411K16Rik is not essential for male fertility [1].

In conclusion, through the KO mouse model-based research, it was revealed that 4933411K16Rik is dispensable for male fertility. This finding contributes to a more efficient allocation of research resources in the exploration of male reproductive biology, preventing unnecessary duplication of efforts in generating knockout mice for genes without an apparent male-fertility-related phenotype [1].

References:

1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by Nuclease technology system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/