Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Rab32em1/Cya
Common Name:
Rab32-KO
Product ID:
S-KO-12472
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rab32-KO
Strain ID
KOCMP-67844-Rab32-B6J-VA
Gene Name
Rab32
Product ID
S-KO-12472
Gene Alias
2810011A17Rik
Background
C57BL/6JCya
NCBI ID
67844
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:1915094
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rab32em1/Cya mice (Catalog S-KO-12472) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019974
NCBI RefSeq
NM_026405
Target Region
Exon 2
Size of Effective Region
~2.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rab32, a member of the Rab small GTPase family, is a key regulator in multiple cellular processes. It is involved in membrane trafficking pathways, especially in endosomal trafficking, and plays important roles in the biogenesis of lysosome-related organelles and host defense against certain pathogenic microbial infections [4].

In glioblastoma multiforme (GBM), Rab32 is significantly elevated, especially in the mesenchymal subtype, and is positively correlated with tumor grade and poor prognosis. Knockdown of Rab32 attenuated GBM migration and invasion, suppressed invasion-related proteins and mesenchymal transition markers. It was found to regulate ERK1/2/Drp1-dependent mitochondrial fission and mesenchymal transition to promote GBM aggressiveness [1].

In the context of intracellular bacterial pathogens, Rab32 and its guanine nucleotide exchange factor BLOC-3 are essential to prevent the growth of Salmonella enterica serovar Typhi in mice, and Rab32 also controls infection by Listeria monocytogenes [2].

In Parkinson's disease, the RAB32 variant c.213C>G (Ser71Arg) cosegregated with autosomal dominant Parkinson's disease in multiple families. Functional studies showed that RAB32 Arg71 activates LRRK2 kinase more than RAB32 Ser71, indicating it as a novel genetic risk factor [3,5].

In rats with peripheral nerve injury, Rab32 facilitates Schwann cell pyroptosis by elevating ROS levels, and silencing Rab32 attenuated this pyroptosis and promoted peripheral nerve regeneration [6].

In summary, Rab32 is crucial in diverse biological processes such as tumor cell migration, host defense against bacteria, and neuronal-related pathologies. The use of gene-knockdown models in different disease contexts has revealed its role in promoting or suppressing disease-related cellular events, providing potential therapeutic targets for GBM, intracellular bacterial infections, Parkinson's disease, and peripheral nerve injuries.

References:

1. Chen, Pin, Lu, Yanbing, He, Binfeng, Huang, Wei, Zhang, Xiaobiao. 2023. Rab32 promotes glioblastoma migration and invasion via regulation of ERK/Drp1-mediated mitochondrial fission. In Cell death & disease, 14, 198. doi:10.1038/s41419-023-05721-3. https://pubmed.ncbi.nlm.nih.gov/36922509/

2. Solano-Collado, Virtu, Rofe, Adam, Spanò, Stefania. 2016. Rab32 restriction of intracellular bacterial pathogens. In Small GTPases, 9, 216-223. doi:10.1080/21541248.2016.1219207. https://pubmed.ncbi.nlm.nih.gov/27645564/

3. Gustavsson, Emil K, Follett, Jordan, Trinh, Joanne, Alessi, Dario R, Farrer, Matthew J. 2024. RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses. In The Lancet. Neurology, 23, 603-614. doi:10.1016/S1474-4422(24)00121-2. https://pubmed.ncbi.nlm.nih.gov/38614108/

4. Ohbayashi, Norihiko, Fukuda, Mitsunori, Kanaho, Yasunori. . Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking. In Journal of biochemistry, 162, 65-71. doi:10.1093/jb/mvx027. https://pubmed.ncbi.nlm.nih.gov/28430987/

5. Hop, Paul J, Lai, Dongbing, Keagle, Pamela J, Kenna, Kevin P, Landers, John E. 2024. Systematic rare variant analyses identify RAB32 as a susceptibility gene for familial Parkinson's disease. In Nature genetics, 56, 1371-1376. doi:10.1038/s41588-024-01787-7. https://pubmed.ncbi.nlm.nih.gov/38858457/

6. Wang, Jiayi, Chen, Pin, Han, Guanjie, He, Binfeng, Lu, Shunyi. 2024. Rab32 facilitates Schwann cell pyroptosis in rats following peripheral nerve injury by elevating ROS levels. In Journal of translational medicine, 22, 194. doi:10.1186/s12967-024-04999-x. https://pubmed.ncbi.nlm.nih.gov/38388913/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest