C57BL/6JCya-Tomm20lem1/Cya
Common Name:
Tomm20l-KO
Product ID:
S-KO-14589
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tomm20l-KO
Strain ID
KOCMP-75266-Tomm20l-B6J-VA
Gene Name
Product ID
S-KO-14589
Gene Alias
4930553D19Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tomm20lem1/Cya mice (Catalog S-KO-14589) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021482
NCBI RefSeq
NM_029227
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Tomm20l is a gene with its function not comprehensively elucidated. However, it has been identified as a testis-enriched gene. Testis-enriched genes play important roles in sperm formation, function, and male fertility. Genetic models, such as knockout (KO) mice, are powerful tools to study its function [1].
In a study generating KO mice for 12 testis-enriched genes including Tomm20l using the Nuclease technology system, it was found that these genes, when individually ablated, are not essential for male fertility, suggesting that Tomm20l alone may not be crucial for male fertility in mice [1]. In another study focused on major depressive disorder (MDD), Tomm20l was identified as one of the deregulated genes potentially related to MDD. The in-vitro validation result of Tomm20l was consistent with the bioinformatics analysis, indicating its possible role as a potential pathological factor in MDD [2].
In conclusion, Tomm20l, as a testis-enriched gene, does not seem to be essential for male fertility based on KO mouse models. Also, its deregulation might be associated with MDD, highlighting its potential importance in understanding the pathogenesis of MDD. These findings from model-based research contribute to a better understanding of the biological functions of Tomm20l and its implications in male fertility and mental disorders.
References:
1. Oyama, Yuki, Miyata, Haruhiko, Shimada, Keisuke, Matzuk, Martin M, Ikawa, Masahito. . Nuclease technology-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. In Asian journal of andrology, 24, 266-272. doi:10.4103/aja.aja_63_21. https://pubmed.ncbi.nlm.nih.gov/34290169/
2. Feng, Jianfei, Zhou, Qing, Gao, Wenquan, Wu, Yanying, Mu, Ruibin. 2019. Seeking for potential pathogenic genes of major depressive disorder in the Gene Expression Omnibus database. In Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 12, e12379. doi:10.1111/appy.12379. https://pubmed.ncbi.nlm.nih.gov/31889427/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen