Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Phpt1em1/Cya
Common Name:
Phpt1-KO
Product ID:
S-KO-14634
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Phpt1-KO
Strain ID
KOCMP-75454-Phpt1-B6N-VA
Gene Name
Phpt1
Product ID
S-KO-14634
Gene Alias
1700008C22Rik; PHP; Php14
Background
C57BL/6NCya
NCBI ID
75454
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:1922704
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Phpt1em1/Cya mice (Catalog S-KO-14634) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000039156
NCBI RefSeq
NM_029293
Target Region
Exon 2
Size of Effective Region
~0.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Phpt1, also known as Phosphohistidine phosphatase 1 or Protein histidine phosphatase (PHP), is an enzyme in eukaryotes that dephosphorylates proteins and peptides phosphorylated on a histidine residue, and it also has a broader specificity as it can dephosphorylate phospholysine in chemically phosphorylated histone H1 and polylysine [3]. It is implicated in various cellular signaling pathways, and has been linked to disease pathways such as in lung cancer development and brown adipocyte differentiation [1,2].

In lung cancer, Phpt1 is overexpressed, correlating with poor overall survival, especially in EGFR-mutant lung cancer cells. Inhibition of Phpt1 expression in these cells decreases proliferation, clonogenicity, and in vitro tumor growth, and it is required for maintaining erlotinib resistance. FBXO32 acts as an E3 ubiquitin ligase for Phpt1, and knockdown of FBXO32 leads to Phpt1 accumulation, activation of the ERK/MAPK pathway, and promotion of lung cancer cell growth [1]. In brown adipocyte differentiation, the expression level of Phpt1 changes during the process, and knockdown of Phpt1 promotes brown adipocyte differentiation while its ectopic expression suppresses it [2].

In conclusion, Phpt1 is involved in crucial biological processes like lung cancer development and brown adipocyte differentiation. In lung cancer, its overexpression and role in drug resistance make it a potential biomarker and therapeutic target. In brown adipocyte differentiation, its regulation of the process suggests a possible link to obesity and related metabolic diseases. The study of Phpt1 through various functional studies, such as knockdown experiments, helps to understand its role in these disease-related biological processes.

References:

1. Zhang, Ning, Liao, Yifeng, Lv, Weize, Xiao, Mei, Zhang, Hongyu. 2022. FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer. In Cellular oncology (Dordrecht, Netherlands), 45, 293-307. doi:10.1007/s13402-022-00669-6. https://pubmed.ncbi.nlm.nih.gov/35411430/

2. Kang, Joo Ae, Kang, Hyun Sup, Bae, Kwang-Hee, Oh, Kyoung-Jin, Kim, Won Kon. . Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation. In Journal of microbiology and biotechnology, 30, 306-312. doi:10.4014/jmb.1909.09003. https://pubmed.ncbi.nlm.nih.gov/31752058/

3. Ek, Pia, Ek, Bo, Zetterqvist, Örjan. 2015. Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine. In Upsala journal of medical sciences, 120, 20-7. doi:10.3109/03009734.2014.996720. https://pubmed.ncbi.nlm.nih.gov/25574816/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest