Plet1, also known as C11orf34, is a gene with diverse functions. It encodes a glycophoshatidylinositol (GPI)-anchored surface protein involved in multiple biological processes. Plet1 is expressed in various cell types and plays roles in cell migration, differentiation, and tissue repair, with potential implications in diseases like psoriasis and colon cancer [1,2,3,4].

In gene-knockout (KO) or conditional-knockout (CKO) mouse models, Plet1 deficiency impaired tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer, suggesting its role in colon tissue repair and tumorigenesis [4]. In murine small intestinal dendritic cells, lack of Plet1 led to aberrant migratory behavior and accumulation in the small intestine [1].

In conclusion, Plet1 is crucial for processes such as cell migration, tissue repair, and trophoblast stem cell differentiation. KO/CKO mouse models have revealed its significance in colon-related diseases, providing insights into potential therapeutic strategies for conditions like colitis-associated cancer and understanding the molecular mechanisms of cell migration in the small intestine [1,4].

References:

1. Karrich, Julien J, Romera-Hernández, Mónica, Papazian, Natalie, Samsom, Janneke N, Cupedo, Tom. 2018. Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells. In European journal of immunology, 49, 290-301. doi:10.1002/eji.201847671. https://pubmed.ncbi.nlm.nih.gov/30537036/

2. Murray, Alexander, Sienerth, Arnold R, Hemberger, Myriam. 2016. Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. In Scientific reports, 6, 25112. doi:10.1038/srep25112. https://pubmed.ncbi.nlm.nih.gov/27121762/

3. Selvakumar, Balachandar, Rah, Bilal, Jagal, Jayalakshmi, Ibrahim, Saleh Mohamed, Samsudin, Rani. 2024. Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model. In Inflammation research : official journal of the European Histamine Research Society ... [et al.], 73, 2217-2230. doi:10.1007/s00011-024-01958-6. https://pubmed.ncbi.nlm.nih.gov/39407062/

4. Zepp, Jarod A, Zhao, Junjie, Liu, Caini, Su, Bing, Li, Xiaoxia. 2017. IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. In Journal of immunology (Baltimore, Md. : 1950), 199, 3849-3857. doi:10.4049/jimmunol.1601540. https://pubmed.ncbi.nlm.nih.gov/29070673/