C57BL/6JCya-Lbhem1/Cya
Common Name
Lbh-KO
Product ID
S-KO-15106
Backgroud
C57BL/6JCya
Strain ID
KOCMP-77889-Lbh-B6J-VA
Status
When using this mouse strain in a publication, please cite “Lbh-KO Mouse (Catalog S-KO-15106) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Lbh-KO
Strain ID
KOCMP-77889-Lbh-B6J-VA
Gene Name
Product ID
S-KO-15106
Gene Alias
1810009F10Rik, 6720416L16Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000024857
NCBI RefSeq
NM_029999
Target Region
Exon 2
Size of Effective Region
~0.1 kb
Overview of Gene Research
Lbh, or Limb-bud and Heart, is a transcription co-factor that is essential for multiple biological processes. It is involved in the WNT pathway and has significance in the development of various tissues. Genetic models, such as gene knockout mice, have been crucial in understanding its functions [1,3].
In triple-negative breast cancer (TNBC), blocking LBH expression causes replication stress due to DNA replication fork stalling, leading to apoptotic cell death and S-G2M cell cycle delays. ATR inhibition combined with LBH downmodulation has a synergistic effect in killing TNBC cells [1]. In cochlear hair cells, Lbh-null mice show progressive hearing loss with stereocilia bundle degeneration and outer hair cell loss, indicating LBH is necessary for hair cell survival [3]. In glioma, LBH promotes cell proliferation, migration, invasion, and in vivo tumor growth, with its upregulation correlating with poor patient survival [2].
In conclusion, LBH plays essential roles in maintaining genome integrity in cancer cells, survival of cochlear hair cells, and progression of glioma. Studies using gene knockout mouse models have been pivotal in revealing these functions, offering potential therapeutic targets for TNBC, hearing loss, and glioma.
References:
1. Garikapati, Koteswararao, Young, In-Chi, Hong, Sunhwa, Jain, Chaitanya, Briegel, Karoline J. 2024. Blocking LBH expression causes replication stress and sensitizes triple-negative breast cancer cells to ATR inhibitor treatment. In Oncogene, 43, 851-865. doi:10.1038/s41388-024-02951-3. https://pubmed.ncbi.nlm.nih.gov/38297083/
2. Liu, Luotong, Luo, Qinglian, Xu, Qian, Xiong, Yu, Deng, Huajiang. 2021. Limb-bud and heart development (LBH) contributes to glioma progression in vitro and in vivo. In FEBS open bio, 12, 211-220. doi:10.1002/2211-5463.13325. https://pubmed.ncbi.nlm.nih.gov/34739189/
3. Liu, Huizhan, Giffen, Kimberlee P, Grati, M'Hamed, Briegel, Karoline J, He, David Z. 2021. Transcription co-factor LBH is necessary for the survival of cochlear hair cells. In Journal of cell science, 134, . doi:10.1242/jcs.254458. https://pubmed.ncbi.nlm.nih.gov/33674448/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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