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C57BL/6NCya-Banf2em1/Cya
Common Name:
Banf2-KO
Product ID:
S-KO-15753
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Banf2-KO
Strain ID
KOCMP-403171-Banf2-B6N-VB
Gene Name
Banf2
Product ID
S-KO-15753
Gene Alias
4930517K23Rik; Baf-L; Baf-like; Gm115
Background
C57BL/6NCya
NCBI ID
403171
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:2684961
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Banf2em1/Cya mice (Catalog S-KO-15753) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037722
NCBI RefSeq
NM_207275
Target Region
Exon 3
Size of Effective Region
~0.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Barrier-to-autointegration factor 2 (Banf2), a paralog of BAF, shows a testis-predominant expression pattern in humans and mice [1,2]. Although the exact function is yet to be fully elucidated, genes with similar expression patterns are involved in processes like germ cell development, spermatid development, and spermatogenesis [2]. Genetic models, such as knockout mice, are valuable tools to study its function.

Using the Nuclease technology system to generate Banf2-knockout mice, researchers found that these knockout mice did not display any detectable abnormalities in the histological structure of the testis, epididymis, ovary, and other tissues, and had normal fertility. This indicates that Banf2 is not essential for mouse spermatogenesis and fertility [1].

In conclusion, despite its testis-predominant expression, Banf2 is not essential for spermatogenesis or fertility in mice as shown by Banf2-knockout mouse models. However, its potential roles in other biological processes or in relation to human male infertility, as suggested by transcriptomic data, still need further exploration [1,2].

References:

1. Niu, Chang-Min, Xia, Meng-Meng, Zhong, Ya-Nan, Zheng, Ying. 2021. Mus musculus Barrier-To-Autointegration Factor 2 (Banf2) is Not Essential for Spermatogenesis or Fertility. In Cytogenetic and genome research, 161, 167-177. doi:10.1159/000513850. https://pubmed.ncbi.nlm.nih.gov/33951625/

2. Omolaoye, Temidayo S, Omolaoye, Victor A, Kandasamy, Richard K, Hachim, Mahmood Yaseen, Du Plessis, Stefan S. 2022. Omics and Male Infertility: Highlighting the Application of Transcriptomic Data. In Life (Basel, Switzerland), 12, . doi:10.3390/life12020280. https://pubmed.ncbi.nlm.nih.gov/35207567/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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