C57BL/6JCya-Coprsem1/Cya
Common Name
Coprs-KO
Product ID
S-KO-16530
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66423-Coprs-B6J-VB
When using this mouse strain in a publication, please cite “Coprs-KO Mouse (Catalog S-KO-16530) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Coprs-KO
Strain ID
KOCMP-66423-Coprs-B6J-VB
Gene Name
Product ID
S-KO-16530
Gene Alias
1700029I03Rik, 2410022L05Rik, Copr5
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033839
NCBI RefSeq
NM_025556.3
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Overview of Gene Research
Coprs, which encodes a histone-binding protein, is highly expressed in the testis. It is essential for targeting the activity of protein arginine N-methyltransferase (Prmt5), and is involved in genome surveillance mechanisms through its role in the repression of retrotransposons, a crucial process for genome integrity during germ cell development [1].
Genetic inactivation of Coprs in mice affects the maturation of spermatogonia to spermatids. In coprs-/-mice, there is deregulation of Miwi and pachytene pre-piRNAs levels, along with derepression of LINE1 repetitive sequences. This indicates that Coprs is implicated in the repression of LINE1 transposons in spermatocytes, suggesting its importance in maintaining genome stability in germ cells [1].
In conclusion, Coprs plays a vital role in germ cell development by being involved in the repression of retrotransposons, especially LINE1 transposons in spermatocytes. The study of Coprs knockout mouse models has provided valuable insights into its function in maintaining genome integrity during germ cell development, highlighting its significance in understanding male germ cell-related biological processes and potential associated diseases [1].
References:
1. Paul, Conception, Delpech, Hélène, Haouzi, Delphine, Sardet, Claude, Fabbrizio, Eric. 2018. Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes. In FEBS open bio, 9, 159-168. doi:10.1002/2211-5463.12562. https://pubmed.ncbi.nlm.nih.gov/30652083/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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