Cyp2j8 is a member of the cytochrome P450 CYP2J subfamily. These enzymes are involved in the metabolism of fatty acids such as arachidonic acid (AA) and linoleic acid (LA) to generate bioactive compounds, which likely play roles in various biological processes [2].

In terms of tissue distribution, Cyp2j8 transcripts were detected in the kidney, liver, and brain, with protein expression confirmed in the kidney and brain (neuropil). It was also found to be expressed in various tissues, with the highest expression in the skin [1,2]. There is no mention of gene knockout (KO) or conditional knockout (CKO) mouse model-based functional studies specific to Cyp2j8 in the provided references.

In summary, Cyp2j8 is an enzyme within the CYP2J subfamily that metabolizes fatty acids, and its tissue-specific expression patterns suggest potential roles in the respective tissues. Although no KO/CKO mouse model data is available from the references, further in vivo studies using such models could potentially reveal more about its function in biological processes and disease conditions.

References:

1. Graves, Joan P, Gruzdev, Artiom, Bradbury, J Alyce, Edin, Matthew L, Zeldin, Darryl C. 2015. Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation. In Drug metabolism and disposition: the biological fate of chemicals, 43, 1169-80. doi:10.1124/dmd.115.064139. https://pubmed.ncbi.nlm.nih.gov/25994032/

2. Graves, Joan P, Edin, Matthew L, Bradbury, J Alyce, Tomer, Kenneth B, Zeldin, Darryl C. 2013. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. In Drug metabolism and disposition: the biological fate of chemicals, 41, 763-73. doi:10.1124/dmd.112.049429. https://pubmed.ncbi.nlm.nih.gov/23315644/