C57BL/6JCya-Bmp10em1/Cya
Common Name:
Bmp10-KO
Product ID:
S-KO-17408
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Bmp10-KO
Strain ID
KOCMP-12154-Bmp10-B6J-VA
Gene Name
Product ID
S-KO-17408
Gene Alias
b2b2711Clo
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Bmp10em1/Cya mice (Catalog S-KO-17408) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032125
NCBI RefSeq
NM_009756.3
Target Region
Exon 2
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Bmp10, a member of the bone morphogenetic protein (BMP) family and the transforming growth factor β (TGFβ) superfamily, plays crucial roles in various biological processes. It is a key regulator in vascular development and cardiogenesis, and is involved in the ALK1-related signaling pathway, which is linked to hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH) [1,3,4]. Bmp10 also contributes to the regulation of iron homeostasis, maintaining cardiac function [2].
In gene-knockout studies, combined loss of zebrafish bmp10 and bmp10-like leads to embryonic lethal cranial arteriovenous malformations (AVMs) similar to acvrl1 mutants, and bmp10 mutants show blood vessel abnormalities, heart dysmorphology, and premature death [4]. In Bmp10-inducible knockout (iKO) mice, AVMs are present in the developing retina, postnatal brain, and adult wounded skin, with increased proliferation and size of endothelial cells in AVM vessels [3]. In zebrafish, mutation of bmp10 results in severe anemia and cardiac hypertrophy due to iron homeostasis dysregulation [2].
In conclusion, Bmp10 is essential for vascular development and maintenance, as well as for regulating iron homeostasis in the heart. Gene-knockout mouse and zebrafish models have significantly contributed to understanding its role in diseases like HHT and iron-related cardiomyopathy, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Desroches-Castan, Agnès, Tillet, Emmanuelle, Bouvard, Claire, Bailly, Sabine. 2021. BMP9 and BMP10: Two close vascular quiescence partners that stand out. In Developmental dynamics : an official publication of the American Association of Anatomists, 251, 178-197. doi:10.1002/dvdy.395. https://pubmed.ncbi.nlm.nih.gov/34240497/
2. Hu, Ruiqin, Li, Genfang, Hu, Peng, Liu, Mingli, Chen, Liangbiao. 2024. bmp10 maintains cardiac function by regulating iron homeostasis. In Journal of genetics and genomics = Yi chuan xue bao, 51, 1459-1473. doi:10.1016/j.jgg.2024.10.003. https://pubmed.ncbi.nlm.nih.gov/39414074/
3. Choi, Hyunwoo, Kim, Bo-Gyeong, Kim, Yong Hwan, Lee, Young Jae, Oh, S Paul. 2022. BMP10 functions independently from BMP9 for the development of a proper arteriovenous network. In Angiogenesis, 26, 167-186. doi:10.1007/s10456-022-09859-0. https://pubmed.ncbi.nlm.nih.gov/36348215/
4. Capasso, Teresa L, Li, Bijun, Volek, Harry J, Kim, Kang, Roman, Beth L. 2019. BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. In Angiogenesis, 23, 203-220. doi:10.1007/s10456-019-09701-0. https://pubmed.ncbi.nlm.nih.gov/31828546/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen