C57BL/6JCya-Cacfd1em1/Cya
Common Name:
Cacfd1-KO
Product ID:
S-KO-17693
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cacfd1-KO
Strain ID
KOCMP-381356-Cacfd1-B6J-VB
Gene Name
Product ID
S-KO-17693
Gene Alias
5930434B04Rik; mFwe
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cacfd1em1/Cya mice (Catalog S-KO-17693) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114006
NCBI RefSeq
NM_029862
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Check the content of the review Cacfd1, details about its key aliases, if any, are not provided in the given references. However, from the context, it seems to be involved in multiple biological processes. In the skeletal muscle, its expression is associated with genes related to endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) pathways, as the SNP rs28539249 in GPSM1 is associated with the skeletal muscle expression of CACFD1 and other genes [2].
In a rat model of chronic glomerulonephritis, Cacfd1 was among the most downregulated genes in the Qi Teng Xiao Zhuo granule group compared with the adriamycin-treated group [3].
Regarding its role in disease, genetic variants in CACFD1 may simultaneously influence COVID-19 severity and coronary heart disease (CHD) risks, with SNPs (rs4962153, rs3094379) near CACFD1 being identified as potentially having such an impact [1].
In conclusion, Cacfd1 appears to be associated with endoplasmic reticulum-related stress responses in skeletal muscle and is involved in the gene expression changes in a rat model of chronic glomerulonephritis. Its genetic variants may play a role in the shared pathology between COVID-19 and CHD. The study of Cacfd1 helps in understanding the biological processes related to these disease conditions and may provide insights for potential therapeutic strategies.
References：
1. Wang, Siyue, Peng, Hexiang, Chen, Feng, Hu, Yonghua, Wu, Tao. 2023. Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases. In Human genomics, 17, 101. doi:10.1186/s40246-023-00547-8. https://pubmed.ncbi.nlm.nih.gov/37964352/
2. Ding, Qiuju, Tan, Amelia Li Min, Parra, E J, Tai, E-Shyong, Chen, Huimei. 2020. Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. In Journal of human genetics, 65, 411-420. doi:10.1038/s10038-019-0720-3. https://pubmed.ncbi.nlm.nih.gov/31959871/
3. Gao, Jia-Rong, Qin, Xiu-Juan, Jiang, Hui, Song, Jun-Mei, Xu, Shuang-Zhi. 2016. The effects of Qi Teng Xiao Zhuo granules, traditional Chinese medicine, on the expression of genes in chronic glomerulonephritis rats. In Journal of ethnopharmacology, 193, 140-149. doi:10.1016/j.jep.2016.08.011. https://pubmed.ncbi.nlm.nih.gov/27497640/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen