C57BL/6JCya-Cyb5rlem1/Cya
Common Name
Cyb5rl-KO
Product ID
S-KO-18069
Backgroud
C57BL/6JCya
Strain ID
KOCMP-230582-Cyb5rl-B6J-VB
Status
When using this mouse strain in a publication, please cite “Cyb5rl-KO Mouse (Catalog S-KO-18069) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Cyb5rl-KO
Strain ID
KOCMP-230582-Cyb5rl-B6J-VB
Gene Name
Product ID
S-KO-18069
Gene Alias
2810410C14Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000106758
NCBI RefSeq
NM_001346552
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Overview of Gene Research
Cyb5rl, a cytochrome b5 reductase homologue, is likely involved in maintaining redox balance. Cytochrome b5 reductases generally participate in electron transfer processes, which are crucial for various cellular functions such as lipid metabolism and oxidative stress response [1].
In a study on a dog with extreme intestinal polyposis, a germline mutation R51X of Cy5rl was found. The commensal gut anaerobe Bacteroides uniformis thrived in this dog and its products, thioredoxin and nitroreductase, could reduce oxidative stress linked to this Cy5rl mutation, decreasing cell death. This indicates that Cy5rl may play a role in the cell death pathway related to oxidative stress in the context of intestinal polyp development [1].
In conclusion, Cy5rl seems to be associated with oxidative stress-related cell death processes, as revealed in the study of a dog model with extreme intestinal polyposis. Understanding the function of Cy5rl in such disease-related contexts could potentially provide insights into the mechanisms of intestinal polyp formation and related diseases.
References：
1. Wang, Jin, Wang, Tianfang, Bishop, Micah A, Bryan, Laura K, Zhao, Shaying. 2018. Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis. In Oncotarget, 9, 29162-29179. doi:10.18632/oncotarget.25646. https://pubmed.ncbi.nlm.nih.gov/30018743/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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