C57BL/6JCya-Trank1em1/Cya
Common Name:
Trank1-KO
Product ID:
S-KO-18281
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Trank1-KO
Strain ID
KOCMP-320429-Trank1-B6J-VB
Gene Name
Product ID
S-KO-18281
Gene Alias
A230061D21Rik; C030048J01Rik; Gm187; Lba1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Trank1em1/Cya mice (Catalog S-KO-18281) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000078626
NCBI RefSeq
NM_001164659
Target Region
Exon 5~6
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
TRANK1, also known as Tetratricopeptide repeat and ankyrin repeat containing 1, has been associated with multiple psychiatric disorders. Although its neuronal function remains relatively unclear, genes highly correlated with TRANK1 are significantly enriched in biological processes related to dendritic spine, synaptic plasticity, axon guidance and circadian entrainment [2].
Genetic analyses have confirmed TRANK1 as a susceptibility gene for bipolar disorder (BD). Lower TRANK1 mRNA expression is a principal BD risk factor [2]. In BD, administration of type 1 interferon can induce the expression of TRANK1, which is associated with elevated circulating biomarkers of the impaired blood-brain barrier. Intestine microbiota-dependent type 1 interferon signalling may induce over-expression of TRANK1, compromising blood-brain barrier integrity and contributing to BD pathogenesis [1]. Also, in a mice model, fecal microbiota transplantation from BD patients led to a depression-like phenotype with elevated TRANK1 mRNA levels in the hippocampus and prefrontal cortex [3].
In Kleine-Levin syndrome (KLS), a genome-wide association study found a strong association within the 3' region of the TRANK1 gene locus, and the gene polymorphisms in conjunction with birth difficulties may predispose to KLS [5]. In schizophrenia, increased plasma IgG antibodies against TRANK1-derived peptide antigens were observed, suggesting it could be a biomarker for a subgroup of schizophrenia [4].
In conclusion, TRANK1 is significantly associated with psychiatric disorders such as bipolar disorder, Kleine-Levin syndrome, and schizophrenia. Through genetic analyses and animal models, it has been revealed that TRANK1 may play important roles in these disorders, potentially by affecting blood-brain barrier integrity, being associated with circadian regulation, and serving as a biomarker. The study of TRANK1 helps to better understand the pathophysiology of these psychiatric diseases and may provide new targets for treatment.
References:
1. Lai, Jianbo, Jiang, Jiajun, Zhang, Peifen, Zhu, Yiyi, Hu, Shaohua. 2021. Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1. In Journal of cellular and molecular medicine, 25, 6463-6469. doi:10.1111/jcmm.16611. https://pubmed.ncbi.nlm.nih.gov/34014031/
2. Li, Wenqiang, Cai, Xin, Li, Hui-Juan, Lv, Luxian, Chang, Hong. 2020. Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. In Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46, 1103-1112. doi:10.1038/s41386-020-00788-4. https://pubmed.ncbi.nlm.nih.gov/32791513/
3. Lai, Jianbo, Zhang, Peifen, Jiang, Jiajun, Zheng, Peng, Hu, Shaohua. 2021. New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data. In Frontiers in immunology, 12, 789647. doi:10.3389/fimmu.2021.789647. https://pubmed.ncbi.nlm.nih.gov/34992606/
4. Whelan, Ruth, St Clair, David, Mustard, Colette J, Hallford, Philomena, Wei, Jun. . Study of Novel Autoantibodies in Schizophrenia. In Schizophrenia bulletin, 44, 1341-1349. doi:10.1093/schbul/sbx175. https://pubmed.ncbi.nlm.nih.gov/29373732/
5. Ambati, Aditya, Hillary, Ryan, Leu-Semenescu, Smaranda, Arnulf, Isabelle, Mignot, Emmanuel Jean-Marie. . Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2005753118. https://pubmed.ncbi.nlm.nih.gov/33737391/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen