Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Itgb2em1/Cya
Common Name:
Itgb2-KO
Product ID:
S-KO-18416
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Itgb2-KO
Strain ID
KOCMP-16414-Itgb2-B6J-VB
Gene Name
Itgb2
Product ID
S-KO-18416
Gene Alias
2E6; Cd18; LAD; LCAMB; Lfa1; MF17
Background
C57BL/6JCya
NCBI ID
16414
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:96611
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Itgb2em1/Cya mice (Catalog S-KO-18416) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000000299
NCBI RefSeq
NM_008404
Target Region
Exon 4~5
Size of Effective Region
~1.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Itgb2, also known as integrin beta 2, is a gene that plays a crucial role in coordinating extracellular and intracellular signaling. Integrins are known to reshape the tumor microenvironment, and Itgb2 is involved in host defense [1]. It has been associated with pathways such as PI3K/AKT/mTOR, which regulate cellular metabolism and growth [1].

In oral squamous cell carcinoma (OSCC), CAFs with higher Itgb2 expression promoted tumor cell proliferation. Itgb2 regulated the PI3K/AKT/mTOR axis to enhance glycolysis in CAFs, and the lactate produced was absorbed by OSCC cells, which then oxidized NADH in the mitochondrial oxidative phosphorylation system to generate ATP [1]. In non-small cell lung cancer, lncRNA ITGB2-AS1 was found to promote cisplatin resistance by inhibiting ferroptosis via activating the FOSL2/NAMPT axis [2]. In severe acute pancreatitis-related acute lung injury, extracellular vesicles overexpressing ITGAM and ITGB2 could attenuate pulmonary inflammation and endothelial cell barrier disruption [3]. In cerebral ischemia-reperfusion injury, Itgb2+ microglia subclusters were involved in energy metabolism, cell cycle, angiogenesis, neuronal myelin formation, and repair at different time points [4]. In glioblastoma, ITGB2 in microglia promoted the mesenchymal transition of GBM cells through the JAK1/STAT3/IL-6 signaling feedback [5]. In diabetic nephropathy, ITGB2 was identified as a potential diagnostic marker [6]. In inflammatory bowel disease, suppression of ITGB2 expression alleviated inflammation in mice, and it may be a potential diagnostic marker for IBD-associated colorectal cancer [7]. In BAP1-mutated uveal melanoma, the ITGB2-ICAM1 axis promoted liver metastasis by preserving hypoxia-and ECM-related signatures [8]. In gliomas, ITGB2 was elevated in higher-malignancy tumors, predicted poor prognosis, and high ITGB2 expression was associated with a better immunotherapy response [9]. In premature infants with necrotizing enterocolitis, although ITGB2 variants were not associated with NEC in the entire cohort, there was a trend towards enrichment with NEC severity in extremely low birthweight infants [10].

In conclusion, Itgb2 is essential in various biological processes and diseases. Studies using different experimental models, though not always gene-knockout or conditional-knockout mouse models, have revealed its role in tumor progression, drug resistance, inflammation-related injuries, and neurodegenerative and kidney diseases. These findings contribute to understanding the molecular mechanisms underlying these diseases and may provide potential therapeutic targets.

References:
1. Zhang, Xiaoxin, Dong, Yingchun, Zhao, Mengxiang, Hu, Qingang, Ni, Yanhong. 2020. ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system. In Theranostics, 10, 12044-12059. doi:10.7150/thno.47901. https://pubmed.ncbi.nlm.nih.gov/33204328/
2. Chen, Huiyong, Wang, Linhui, Liu, Jingting, Liao, Hongliang, Wan, Renping. . LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. In Cancer biology & therapy, 24, 2223377. doi:10.1080/15384047.2023.2223377. https://pubmed.ncbi.nlm.nih.gov/37370246/
3. Hu, Qian, Zhang, Shu, Yang, Yue, Lyon, Christopher J, Wan, Meihua. 2023. Extracellular Vesicle ITGAM and ITGB2 Mediate Severe Acute Pancreatitis-Related Acute Lung Injury. In ACS nano, 17, 7562-7575. doi:10.1021/acsnano.2c12722. https://pubmed.ncbi.nlm.nih.gov/37022097/
4. Zeng, Fanning, Cao, Jun, Hong, Zexuan, Zou, Xin, Tao, Tao. 2023. Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral occlusion mice model. In Frontiers in immunology, 14, 1114663. doi:10.3389/fimmu.2023.1114663. https://pubmed.ncbi.nlm.nih.gov/37063847/
5. Xie, Han, Jiang, Yanyi, Xiang, Yufei, Tian, Dasheng, Bian, Erbao. . Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia. In Neuro-oncology, 26, 1438-1452. doi:10.1093/neuonc/noae065. https://pubmed.ncbi.nlm.nih.gov/38554116/
6. Xu, Mingming, Zhou, Hang, Hu, Ping, Liu, Li, Liu, Xiaoqiang. 2023. Identification and validation of immune and oxidative stress-related diagnostic markers for diabetic nephropathy by WGCNA and machine learning. In Frontiers in immunology, 14, 1084531. doi:10.3389/fimmu.2023.1084531. https://pubmed.ncbi.nlm.nih.gov/36911691/
7. Xu, Rong, Du, Wei, Yang, Qinglong, Du, Ashuai. . ITGB2 related to immune cell infiltration as a potential therapeutic target of inflammatory bowel disease using bioinformatics and functional research. In Journal of cellular and molecular medicine, 28, e18501. doi:10.1111/jcmm.18501. https://pubmed.ncbi.nlm.nih.gov/39088353/
8. Li, Jiaoduan, Cao, Dongyan, Jiang, Lixin, Zhuang, Ai, Xiang, Dongxi. 2023. ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures. In Cellular oncology (Dordrecht, Netherlands), 47, 951-965. doi:10.1007/s13402-023-00908-4. https://pubmed.ncbi.nlm.nih.gov/38150154/
9. Xu, Houshi, Zhang, Anke, Han, Xiaying, Wang, Wei, Lou, Meiqing. 2021. ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas. In Cancer immunology, immunotherapy : CII, 71, 645-660. doi:10.1007/s00262-021-03022-2. https://pubmed.ncbi.nlm.nih.gov/34313821/
10. George, Lovya, Menden, Heather, Xia, Sheng, Farrow, Emily, Sampath, Venkatesh. . ITGB2 (Integrin β2) Immunomodulatory Gene Variants in Premature Infants With Necrotizing Enterocolitis. In Journal of pediatric gastroenterology and nutrition, 72, e37-e41. doi:10.1097/MPG.0000000000002941. https://pubmed.ncbi.nlm.nih.gov/32925548/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest