C57BL/6JCya-Adgrb1em1/Cya
Common Name:
Adgrb1-KO
Product ID:
S-KO-18453
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Adgrb1-KO
Strain ID
KOCMP-107831-Adgrb1-B6J-VB
Gene Name
Product ID
S-KO-18453
Gene Alias
B830018M07Rik; Bai1; mKIAA4089
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adgrb1em1/Cya mice (Catalog S-KO-18453) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000042035
NCBI RefSeq
NM_174991
Target Region
Exon 19
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Adgrb1, also known as BAI1, belongs to the adhesion G protein-coupled receptor family. It plays important roles in multiple biological processes such as suppressing angiogenesis, mediating phagocytosis, and regulating dendritic spine and excitatory synapse development. It is also involved in signaling pathways related to Rac and Rho, and is crucial for brain development and synaptic function [1,2,3]. Genetic models like knockout (KO) mice are valuable for studying Adgrb1's functions.
In Adgrb1 -/- mice, significant social behavior deficits, increased seizure susceptibility, delayed growth, and reduced brain weight were observed. There was also reduced neuron density and increased apoptosis during brain development in the hippocampus, indicating the essential role of Adgrb1 in normal brain development and function [2]. Additionally, a schizophrenia-associated genetic variant near Adgrb1 may regulate its expression, suggesting Adgrb1's potential involvement in schizophrenia-related pathways [4,5].
In conclusion, Adgrb1 is essential for normal brain development and synaptic function, and its dysregulation may be associated with neurological disorders such as schizophrenia and abnormal social behavior and seizure susceptibility as revealed by KO mouse models. The study of Adgrb1 provides insights into the underlying mechanisms of these diseases and potential therapeutic targets.
References：
1. Hamann, Jörg, Aust, Gabriela, Araç, Demet, Langenhan, Tobias, Schiöth, Helgi B. . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. In Pharmacological reviews, 67, 338-67. doi:10.1124/pr.114.009647. https://pubmed.ncbi.nlm.nih.gov/25713288/
2. Shiu, Fu Hung, Wong, Jennifer C, Yamamoto, Takahiro, Hall, Randy A, Escayg, Andrew. 2022. Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development. In Experimental neurology, 351, 113994. doi:10.1016/j.expneurol.2022.113994. https://pubmed.ncbi.nlm.nih.gov/35114205/
3. Lala, Trisha, Doan, Juleva K, Takatsu, Hiroyuki, Shin, Hye-Won, Hall, Randy A. 2022. Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity. In The Journal of biological chemistry, 298, 102685. doi:10.1016/j.jbc.2022.102685. https://pubmed.ncbi.nlm.nih.gov/36370845/
4. Wahbeh, Marah H, Boyd, Rachel J, Yovo, Christian, McCallion, Andrew S, Avramopoulos, Dimitrios. 2024. A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes. In HGG advances, 5, 100303. doi:10.1016/j.xhgg.2024.100303. https://pubmed.ncbi.nlm.nih.gov/38702885/
5. Wahbeh, Marah H, Boyd, Rachel J, Yovo, Christian, McCallion, Andrew S, Avramopoulos, Dimitrios. 2023. A Functional Schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.12.18.570831. https://pubmed.ncbi.nlm.nih.gov/38187620/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen