Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Mybl2em1/Cya
Common Name:
Mybl2-KO
Product ID:
S-KO-18503
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Mybl2-KO
Strain ID
KOCMP-17865-Mybl2-B6J-VA
Gene Name
Mybl2
Product ID
S-KO-18503
Gene Alias
B-Myb; Bmyb
Background
C57BL/6JCya
NCBI ID
17865
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:101785
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mybl2em1/Cya mice (Catalog S-KO-18503) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000018005
NCBI RefSeq
NM_008652
Target Region
Exon 5
Size of Effective Region
~0.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MYBL2, also known as B-MYB, is a transcription factor of the MYB transcription factor family. It is essential in regulating vital cellular processes such as cell proliferation, differentiation, DNA repair, and cell cycle progression. It also plays a role in cell survival [2]. Dysregulation of these processes is associated with cancer development, making MYBL2 a gene of significant interest in cancer research. Genetically engineered mouse models can be valuable tools for studying MYBL2's functions.

In various cancers, MYBL2 shows oncogenic properties. In bladder cancer, MYBL2 deficiency suppressed cell proliferation and migration in vitro and in vivo, while overexpression had the opposite effect. MYBL2 could bind to and transactivate the promoter of CDCA3, promoting the malignant phenotype of bladder cancer cells [1]. In prostate cancer, genetic inhibition of Mybl2 in murine prostate cancer cell lines representing phenotypic plasticity decreased in vivo growth, cell fitness, and repressed gene expression signatures related to pluripotency and stemness [3]. In ovarian cancer, tumor-derived MYBL2 indicated poor prognosis, and its inhibition could reprogram the tumor microenvironment and reduce anti-PD-1 resistance [4].

In conclusion, MYBL2 is a central regulator of cell-related processes. Through model-based research, especially gene knockout (KO) or conditional knockout (CKO) mouse models, its role in promoting cancer progression in multiple cancer types has been revealed. These findings contribute to understanding the mechanisms of cancer development and offer potential therapeutic targets for treating related diseases.

References:
1. Liu, Wei, Shen, Dexin, Ju, Lingao, Xiao, Yu, Wang, Xinghuan. 2022. MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. In Oncogene, 41, 4606-4617. doi:10.1038/s41388-022-02456-x. https://pubmed.ncbi.nlm.nih.gov/36071275/
2. Musa, Julian, Aynaud, Marie-Ming, Mirabeau, Olivier, Delattre, Olivier, Grünewald, Thomas Gp. 2017. MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis. In Cell death & disease, 8, e2895. doi:10.1038/cddis.2017.244. https://pubmed.ncbi.nlm.nih.gov/28640249/
3. German, Beatriz, Alaiwi, Sarah A, Ho, Kun-Lin, Lawrenson, Kate, Ellis, Leigh. . MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer. In Cancer research communications, 4, 2295-2307. doi:10.1158/2767-9764.CRC-24-0069. https://pubmed.ncbi.nlm.nih.gov/39113611/
4. Pan, Baoyue, Wan, Ting, Zhou, Yun, Li, Jundong, Zheng, Min. 2023. The MYBL2-CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages. In Cancer cell international, 23, 248. doi:10.1186/s12935-023-03079-2. https://pubmed.ncbi.nlm.nih.gov/37865750/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest