C57BL/6JCya-Ccr6em1/Cya
Common Name
Ccr6-KO
Product ID
S-KO-18593
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12458-Ccr6-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ccr6-KO Mouse (Catalog S-KO-18593) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ccr6-KO
Strain ID
KOCMP-12458-Ccr6-B6J-VB
Gene Name
Product ID
S-KO-18593
Gene Alias
CCR-6, KY411, Cmkbr6, CC-CKR-6
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000097418
NCBI RefSeq
NM_009835
Target Region
Exon 5~6
Size of Effective Region
~4.2 kb
Overview of Gene Research
Ccr6, a G protein-coupled receptor, is unique as it binds only to the chemokine ligand CCL20 [2,4]. It is expressed on various immune cells such as B cells, immature dendritic cells, innate lymphoid cells, regulatory CD4 T cells, and Th17 cells [1]. The CCR6-CCL20 axis is involved in leukocyte migration, immune homeostasis, and activation, playing a crucial role in mucosal immunity, for example, mediating the recruitment of immune cells to epithelial inflammation sites [1,2,4].
In colitis-associated carcinoma, SMAD4 loss in mouse colon epithelium led to increased CCL20 expression and recruitment of CCR6+ immune cells like T regulatory, Th17, and dendritic cells. Deletion of the Ccr6 gene abrogated these immune responses and significantly reduced the incidence of colitis-associated tumors, indicating that Ccr6 contributes to colon cancer susceptibility through CCL20-mediated inflammation [3].
In conclusion, Ccr6 is essential in immune-related biological processes, especially in mucosal immunity and immune cell recruitment. Gene knockout studies in mice, such as the Ccr6 deletion in the context of SMAD4-related colitis-associated carcinoma, have revealed its role in disease-related inflammation and carcinogenesis, highlighting its potential as a therapeutic target in related diseases.
References：
1. Meitei, Heikrujam Thoihen, Jadhav, Nandadeep, Lal, Girdhari. 2021. CCR6-CCL20 axis as a therapeutic target for autoimmune diseases. In Autoimmunity reviews, 20, 102846. doi:10.1016/j.autrev.2021.102846. https://pubmed.ncbi.nlm.nih.gov/33971346/
2. Gómez-Melero, Sara, Caballero-Villarraso, Javier. 2023. CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases. In Antibodies (Basel, Switzerland), 12, . doi:10.3390/antib12020030. https://pubmed.ncbi.nlm.nih.gov/37092451/
3. Hanna, David N, Smith, Paula Marincola, Novitskiy, Sergey V, Beauchamp, R Daniel, Means, Anna L. 2022. SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation. In Gastroenterology, 163, 1334-1350.e14. doi:10.1053/j.gastro.2022.07.016. https://pubmed.ncbi.nlm.nih.gov/35863523/
4. Ito, Toshihiro, Carson, William F, Cavassani, Karen A, Connett, Judith M, Kunkel, Steven L. . CCR6 as a mediator of immunity in the lung and gut. In Experimental cell research, 317, 613-9. doi:10.1016/j.yexcr.2010.12.018. https://pubmed.ncbi.nlm.nih.gov/21376174/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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