C57BL/6JCya-Mug1em1/Cya
Common Name:
Mug1-KO
Product ID:
S-KO-18923
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Mug1-KO
Strain ID
KOCMP-17836-Mug1-B6J-VA
Gene Name
Product ID
S-KO-18923
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mug1em1/Cya mice (Catalog S-KO-18923) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032228
NCBI RefSeq
NM_008645
Target Region
Exon 2~4
Size of Effective Region
~2.5 kb
Detailed Document
Overview of Gene Research
Mug1 has different functions in distinct organisms.
In plants, MUG1 is a MULE transposon-related domesticated gene in Oryza species. It shows diverse expression levels in different tissues of O. sativa, and its sequence diversity, neutrality, and phylogenetics have been studied. Nucleotide diversity is higher than functionally known genes in rice, and purifying selection is suggested in its sequences [2].
In the rice blast fungus Magnaporthe oryzae, the Magnaporthe-unique gene MUG1 is crucial for fungal virulence and conidiation. Gene knockout and phenotypic analysis revealed that deletion mutants of MUG1 had reduced appressorial turgor pressure and invasive hyphal development, indicating its vital role in infection-related morphogenesis and virulence [1].
In summary, Mug1 has important functions in plants and fungi. In Oryza species, it is involved in aspects related to transposon-domestication and sequence-related characteristics. In rice blast fungi, it significantly impacts fungal infection and virulence, which is revealed through gene knockout studies. Understanding Mug1's functions helps in better comprehending plant-fungal interactions and plant genetic evolution.
References：
1. Zhang, Huixia, Chen, Zhiyi, Yu, Zechen, Lu, Xunli, Yang, Jun. 2024. Magnaporthe-Unique Gene MUG1 Is Important for Fungal Appressorial Penetration, Invasive Hyphal Extension, and Virulence in Rice Blast Fungi. In Journal of fungi (Basel, Switzerland), 10, . doi:10.3390/jof10080511. https://pubmed.ncbi.nlm.nih.gov/39194837/
2. Kwon, Soon-Jae, Park, Kyong-Cheul, Son, Jae-Han, Park, Cheul-Ho, Kim, Nam-Soo. 2009. Sequence diversity of a domesticated transposase gene, MUG1, in Oryza species. In Molecules and cells, 27, 459-65. doi:10.1007/s10059-009-0061-8. https://pubmed.ncbi.nlm.nih.gov/19390827/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen