C57BL/6JCya-Nol10em1/Cya
Common Name
Nol10-KO
Product ID
S-KO-18999
Backgroud
C57BL/6JCya
Strain ID
KOCMP-217431-Nol10-B6J-VB
When using this mouse strain in a publication, please cite “Nol10-KO Mouse (Catalog S-KO-18999) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Nol10-KO
Strain ID
KOCMP-217431-Nol10-B6J-VB
Gene Name
Product ID
S-KO-18999
Gene Alias
Gm67
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 12
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000046011
NCBI RefSeq
NM_001008421
Target Region
Exon 2~3
Size of Effective Region
~3.5 kb
Overview of Gene Research
Nol10, also known as polyglutamine binding protein 5 (PQBP5), is an intrinsically disordered protein expressed in the nucleolus. It makes up the skeletal structure of the nucleolus, forming the granule meshwork in the granular component area. PQBP5/Nol10 is essential for maintaining the nucleolus structure under physiological and osmotic stress conditions. It also functions as an anchor for the reassembly of other nucleolar proteins during stress [1].
In a mouse model of NUP98::DDX10 leukemia, loss of Nol10 impaired disease progression and improved survival. Nol10 acts cooperatively with NUP98::DDX10 to regulate serine biosynthesis pathways and stabilize ATF4 mRNA, suggesting it is a critical regulator of this type of leukemia [2].
In conclusion, Nol10 is crucial for maintaining nucleolar structure and function. Its role in leukemia development, as revealed by the NUP98::DDX10 leukemia mouse model, highlights its potential as a therapeutic target in this disease area.
References：
1. Jin, Xiaocen, Tanaka, Hikari, Jin, Meihua, Ando, Toshio, Okazawa, Hitoshi. 2023. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. In Nature communications, 14, 9. doi:10.1038/s41467-022-35602-w. https://pubmed.ncbi.nlm.nih.gov/36599853/
2. Shima, Yutaka, Yamagata, Kazutsune, Kuroki, Yoko, Aikawa, Yukiko, Kitabayashi, Issay. 2025. Loss of NOL10 leads to impaired disease progression of NUP98::DDX10 leukemia. In Leukemia, , . doi:10.1038/s41375-025-02607-5. https://pubmed.ncbi.nlm.nih.gov/40263434/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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