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C57BL/6JCya-Mrps10em1/Cya
Common Name:
Mrps10-KO
Product ID:
S-KO-19062
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Mrps10-KO
Strain ID
KOCMP-64657-Mrps10-B6J-VB
Gene Name
Mrps10
Product ID
S-KO-19062
Gene Alias
1110038B19Rik; Rpms10
Background
C57BL/6JCya
NCBI ID
64657
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:1928139
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrps10em1/Cya mice (Catalog S-KO-19062) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000119945
NCBI RefSeq
NM_001146212
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mrps10, a mitochondrial ribosomal protein gene, is an essential component for the structural and functional integrity of the mitoribosome complex. Mitoribosomes play a crucial role in mitochondrial translation, which is vital for the production of proteins involved in oxidative phosphorylation and energy metabolism. The gene is expressed throughout early embryogenesis with little stage or tissue specificity [1].

In a study on pigs, Mrps10 was identified as a hub gene in a protein-protein interaction network related to abdominal subcutaneous fat deposition. It was also recognized as a potential obese-specific biomarker, suggesting its role in fat metabolism-related biological processes [2]. In pancreatic ductal adenocarcinoma, a 5-gene signature including Mrps10 was associated with poor survival, potentially playing a role in immunosuppression [3]. In intervertebral disc degeneration, Mrps10 was identified as a target of hsa-miR-508-5p, with its up-regulation in the IDD group [4]. In intensive care unit-acquired weakness, miR-542-3p suppressed the expression of Mrps10, suggesting mitochondrial ribosomal stress [5]. In breast cancer cell line screening, overexpression of Mrps10 was observed, and its protein-protein interactions indicated a putative role in fatty acid oxidation regulated by the brain-derived neurotrophic factor signaling pathway [6]. In a study on rheumatoid arthritis, Mrps10 was identified as one of the key biomarkers related to energy and ROS metabolism, and its regulatory network and potential drug targets were explored [7].

In conclusion, Mrps10 is crucial for the mitoribosome complex's function. Studies in various disease models such as obesity, pancreatic cancer, intervertebral disc degeneration, intensive care unit-acquired weakness, breast cancer, and rheumatoid arthritis have revealed its diverse roles in different biological processes and disease conditions, highlighting its potential as a biomarker and a target for further research in these disease areas.

References:
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. Yang, Yongli, Wang, Xiaoyi, Li, Mingli, Chen, Qiang, Lu, Shaoxiong. 2024. Identification of potential obese-specific biomarkers and pathways associated with abdominal subcutaneous fat deposition in pig using a comprehensive bioinformatics strategy. In PeerJ, 12, e17486. doi:10.7717/peerj.17486. https://pubmed.ncbi.nlm.nih.gov/38832038/
3. Kisling, Sophia G, Atri, Pranita, Shah, Ashu, Ghersi, Dario, Batra, Surinder K. . A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma. In Clinical cancer research : an official journal of the American Association for Cancer Research, 29, 3759-3770. doi:10.1158/1078-0432.CCR-23-0825. https://pubmed.ncbi.nlm.nih.gov/37432996/
4. Gholipour, Akram, Malakootian, Mahshid, Oveisee, Maziar. 2023. hsa-miR-508-5p as a New Potential Player in Intervertebral Disc Degeneration. In International journal of molecular and cellular medicine, 11, 137-149. doi:10.22088/IJMCM.BUMS.11.2.137. https://pubmed.ncbi.nlm.nih.gov/37091041/
5. Garros, Roser Farre, Paul, Richard, Connolly, Martin, Polkey, Michael I, Kemp, Paul R. . MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness. In American journal of respiratory and critical care medicine, 196, 1422-1433. doi:10.1164/rccm.201701-0101OC. https://pubmed.ncbi.nlm.nih.gov/28809518/
6. Revathi Paramasivam, Oviya, Gopisetty, Gopal, Subramani, Jayavelu, Thangarajan, Rajkumar. . Expression and affinity purification of recombinant mammalian mitochondrial ribosomal small subunit (MRPS) proteins and protein-protein interaction analysis indicate putative role in tumourigenic cellular processes. In Journal of biochemistry, 169, 675-692. doi:10.1093/jb/mvab004. https://pubmed.ncbi.nlm.nih.gov/34492114/
7. Gao, Conghui, Zhang, Chengqiang, Wen, Lixing, Duan, Jiaoniu, Guo, Yingying. 2025. Regulation of reactive oxygen species and the role of mitochondrial apoptotic-related genes in rheumatoid arthritis. In Scientific reports, 15, 2165. doi:10.1038/s41598-025-85460-x. https://pubmed.ncbi.nlm.nih.gov/39820483/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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