C57BL/6JCya-AA467197em1/Cya
Common Name:
AA467197-KO
Product ID:
S-KO-19127
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
AA467197-KO
Strain ID
KOCMP-433470-AA467197-B6J-VA
Gene Name
Product ID
S-KO-19127
Gene Alias
Nmes1; mir-147
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-AA467197em1/Cya mice (Catalog S-KO-19127) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047498
NCBI RefSeq
NM_001004174
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Aa467197, also known as Nmes1 (Normal Mucosa of Esophagus-Specific gene 1), is a novel regulator involved in mucosal healing. It influences the macrophage response to the tissue-remodeling cytokine IL-4, suggesting its role in pathways related to tissue repair and immune-mediated responses [1].
In murine models, the ablation of Nmes1 (Aa467197) led to decreased intestinal regeneration during the recovery phase of colitis, while enhancing parasitic egg clearance and reducing fibrosis during the advanced stages of Schistosoma mansoni infection. These changes were associated with alterations in CX3CR1+ macrophages, known for their wound-healing potential in the inflamed colon [1]. Additionally, in a study on food allergies in mice, weighted Gene Co-Expression Network Analysis (WGCNA) showed a positive correlation between Aa467197 expression and oral exposure to nanoplastics or OVA sensitization, suggesting its involvement in the exacerbation of food allergies through mechanisms like increased intestinal permeability and gut microbiota dysbiosis [2].
In conclusion, Aa467197 plays a crucial role in mucosal healing processes, as demonstrated by gene-knockout (KO) mouse models in colitis and Schistosoma mansoni infection scenarios. It also appears to be involved in the modulation of food allergy-related mechanisms, highlighting its significance in understanding and potentially treating colon-associated inflammation and food allergy-related diseases.
References:
1. Hamley, Madeleine, Leyk, Stephanie, Casar, Christian, Henao-Mejia, Jorge, Bosurgi, Lidia. 2023. Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. In European journal of immunology, 54, e2350434. doi:10.1002/eji.202350434. https://pubmed.ncbi.nlm.nih.gov/37971166/
2. Okamura, Takuro, Hasegawa, Yuka, Ohno, Yuriko, Takano, Hirohisa, Fukui, Michiaki. 2025. Oral exposure to nanoplastics and food allergy in mice fed a normal or high-fat diet. In Chemosphere, 379, 144401. doi:10.1016/j.chemosphere.2025.144401. https://pubmed.ncbi.nlm.nih.gov/40252413/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen