C57BL/6JCya-Rps19bp1em1/Cya
Common Name
Rps19bp1-KO
Product ID
S-KO-19169
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66538-Rps19bp1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Rps19bp1-KO Mouse (Catalog S-KO-19169) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Rps19bp1-KO
Strain ID
KOCMP-66538-Rps19bp1-B6J-VA
Gene Name
Product ID
S-KO-19169
Gene Alias
S19BP, 2510038A11Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000052499
NCBI RefSeq
NM_175109
Target Region
Exon 3~4
Size of Effective Region
~1.8 kb
Overview of Gene Research
Rps19bp1, the function of which is not fully elucidated, has been associated with multiple biological processes. It is involved in ribosome biogenesis as it participates in 40 S ribosomal subunit assembly, which in turn promotes erythropoiesis [1]. Additionally, it may be related to protein-folding processes in pancreatic β-cells, as its expression was altered in diabetic β-cells [3].
In a study using conditional knockout mouse models, depletion of Atf4 in hematopoietic cells led to erythroid differentiation defects due to the down-regulation of Rps19bp1. ATF4 was found to directly regulate Rps19bp1 transcription, highlighting the importance of the ATF4-Rps19bp1 axis in promoting erythropoiesis [1]. In prostate cancer, the LINC00106/Rps19bp1/p53 axis was identified, where LINC00106 and Rps19bp1 interact to prevent p53 activity, promoting the proliferation and migration of prostate cancer cells [2].
In conclusion, Rps19bp1 is crucial for erythropoiesis through its role in ribosome biogenesis and may also contribute to cancer-related processes such as the proliferation and migration of prostate cancer cells. The use of gene knockout and conditional knockout mouse models has significantly enhanced our understanding of Rps19bp1's functions in erythropoiesis and cancer-related biological processes.
References：
1. Zheng, Zhaofeng, Yang, Shangda, Gou, Fanglin, Cheng, Hui, Cheng, Tao. . The ATF4-RPS19BP1 axis modulates ribosome biogenesis to promote erythropoiesis. In Blood, 144, 742-756. doi:10.1182/blood.2023021901. https://pubmed.ncbi.nlm.nih.gov/38657191/
2. Lu, Lingxiang, Tian, Zhen, Lu, Jicheng, Guo, Shuai, Huang, Yuhua. 2023. LINC00106/RPS19BP1/p53 axis promotes the proliferation and migration of human prostate cancer cells. In PeerJ, 11, e15232. doi:10.7717/peerj.15232. https://pubmed.ncbi.nlm.nih.gov/37180577/
3. Klyosova, Elena, Azarova, Iuliia, Buikin, Stepan, Polonikov, Alexey. 2023. Differentially Expressed Genes Regulating Glutathione Metabolism, Protein-Folding, and Unfolded Protein Response in Pancreatic β-Cells in Type 2 Diabetes Mellitus. In International journal of molecular sciences, 24, . doi:10.3390/ijms241512059. https://pubmed.ncbi.nlm.nih.gov/37569434/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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