C57BL/6JCya-Ppp1r17em1/Cya
Common Name
Ppp1r17-KO
Product ID
S-KO-19279
Backgroud
C57BL/6JCya
Strain ID
KOCMP-19051-Ppp1r17-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ppp1r17-KO Mouse (Catalog S-KO-19279) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ppp1r17-KO
Strain ID
KOCMP-19051-Ppp1r17-B6J-VB
Gene Name
Product ID
S-KO-19279
Gene Alias
Gsbs, Ppp1r2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000052827
NCBI RefSeq
NM_011153
Target Region
Exon 3~4
Size of Effective Region
~1.2 kb
Overview of Gene Research
Ppp1r17, Protein Phosphatase 1 Regulatory Subunit 17, is involved in multiple biological processes. It is associated with the regulation of synaptic function within neurons, and its phosphorylation and nuclear-cytoplasmic translocation, regulated by cGMP-dependent protein kinase G (PKG; Prkg1), can affect gene expression [1]. It may also be involved in neural progenitor cell cycle progression as it slows down this process [3].
In mice, DMHPpp1r17 neurons (neurons in the dorsomedial hypothalamus marked by Ppp1r17 expression) regulate aging and lifespan. Their regulation occurs through hypothalamic-adipose inter-tissue communication, where they control physical activity and white adipose tissue (WAT) function, including the secretion of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) via sympathetic nervous stimulation [1]. Additionally, in ob/ob mice, PPP1R17-expressing neurons in the DMH are activated by increased food intake and in turn restrict intake to limit overconsumption [2].
In conclusion, Ppp1r17 is crucial in the regulation of physiological processes such as aging, lifespan, and food intake. Studies in mouse models have revealed its role in hypothalamic-adipose communication and the control of food intake, which are important in understanding mammalian aging and energy homeostasis.
References：
1. Tokizane, Kyohei, Brace, Cynthia S, Imai, Shin-Ichiro. 2024. DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication. In Cell metabolism, 36, 377-392.e11. doi:10.1016/j.cmet.2023.12.011. https://pubmed.ncbi.nlm.nih.gov/38194970/
2. Caglar, Caner, Friedman, Jeffrey. . Restriction of food intake by PPP1R17-expressing neurons in the DMH. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2100194118. https://pubmed.ncbi.nlm.nih.gov/33753517/
3. Girskis, Kelly M, Stergachis, Andrew B, DeGennaro, Ellen M, Greenberg, Michael E, Walsh, Christopher A. 2021. Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions. In Neuron, 109, 3239-3251.e7. doi:10.1016/j.neuron.2021.08.005. https://pubmed.ncbi.nlm.nih.gov/34478631/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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