C57BL/6JCya-Cd83em1/Cya
Common Name:
Cd83-KO
Product ID:
S-KO-19437
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cd83-KO
Strain ID
KOCMP-12522-Cd83-B6J-VB
Gene Name
Product ID
S-KO-19437
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cd83em1/Cya mice (Catalog S-KO-19437) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000015540
NCBI RefSeq
NM_009856
Target Region
Exon 3
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Cd83, a member of the immunoglobulin (Ig) superfamily, is expressed in membrane-bound (mCD83) and soluble (sCD83) forms. It is expressed on mature dendritic cells (DCs), activated B cells, T cells, and other immune cells [1,2,3]. Cd83 is involved in regulating immune responses, including the differentiation of T and B lymphocytes, and is crucial for maintaining the balance between tolerance and inflammation [2]. It also plays a role in DC maturation, activation, and homeostasis [3].
In immune thrombocytopenia (ITP), ITP patients show higher CD83 expression. Down-regulation of DC-CD83 inhibits CD4+ T cell proliferation, while over-expression promotes it. siRNA-CD83 can reverse Th1/Th2 and Th17/Tregs polarization, indicating CD83's important role in ITP pathogenesis [4]. In uveitis, CD83+ B cells, the main source of sCD83, alleviate symptoms by inhibiting DCs through sCD83, suggesting their potential therapeutic role [5]. Soluble CD83 can also modulate human-monocyte-derived macrophages toward an alternative phenotype, function, and metabolism, with potential as a new therapeutic agent for inflammatory conditions [6].
In conclusion, Cd83 is a key regulatory molecule in the immune system. Its functions in immune response regulation, as revealed through studies in disease models like ITP and uveitis, highlight its potential importance in understanding and treating autoimmune and inflammatory diseases.
References:
1. Riaz, Bushra, Islam, S M Shamsul, Ryu, Hye Myung, Sohn, Seonghyang. 2023. CD83 Regulates the Immune Responses in Inflammatory Disorders. In International journal of molecular sciences, 24, . doi:10.3390/ijms24032831. https://pubmed.ncbi.nlm.nih.gov/36769151/
2. Grosche, Linda, Knippertz, Ilka, König, Christina, Steinkasserer, Alexander, Lechmann, Matthias. 2020. The CD83 Molecule - An Important Immune Checkpoint. In Frontiers in immunology, 11, 721. doi:10.3389/fimmu.2020.00721. https://pubmed.ncbi.nlm.nih.gov/32362900/
3. Li, Ziduo, Ju, Xinsheng, Silveira, Pablo A, Hart, Derek N J, Clark, Georgina J. 2019. CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential. In Frontiers in immunology, 10, 1312. doi:10.3389/fimmu.2019.01312. https://pubmed.ncbi.nlm.nih.gov/31231400/
4. Wang, Xiuli, Zhou, Qiyuan, Yang, Wen, Zhou, Yongchun, Zhou, Zeping. 2024. The role of CD83 in the pathogenesis of immune thrombocytopenia. In Hematology (Amsterdam, Netherlands), 29, 2372482. doi:10.1080/16078454.2024.2372482. https://pubmed.ncbi.nlm.nih.gov/38994874/
5. Feng, Meng, Wang, Xin, Zhou, Shuping, Wei, Xunbin, Lin, Wei. 2023. CD83+ B cells alleviate uveitis through inhibiting DCs by sCD83. In Immunology, 170, 134-153. doi:10.1111/imm.13654. https://pubmed.ncbi.nlm.nih.gov/37137669/
6. Peckert-Maier, Katrin, Wild, Andreas B, Sprißler, Laura, Steinkasserer, Alexander, Royzman, Dmytro. 2023. Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism. In Frontiers in immunology, 14, 1293828. doi:10.3389/fimmu.2023.1293828. https://pubmed.ncbi.nlm.nih.gov/38162675/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen