Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cpsf1em1/Cya
Common Name:
Cpsf1-KO
Product ID:
S-KO-19801
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cpsf1-KO
Strain ID
KOCMP-94230-Cpsf1-B6J-VB
Gene Name
Cpsf1
Product ID
S-KO-19801
Gene Alias
CPSF160
Background
C57BL/6JCya
NCBI ID
94230
Modification
Conventional knockout
Chromosome
15
Phenotype
MGI:2679722
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cpsf1em1/Cya mice (Catalog S-KO-19801) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000230157
NCBI RefSeq
NM_001164173
Target Region
Exon 2~25
Size of Effective Region
~5.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cpsf1, also known as cleavage and polyadenylation specificity factor 1, is a critical factor involved in alternative polyadenylation (APA), a common RNA modification process. It plays a role in the 3' untranslated region processing of a subset of pre-mRNAs, which is essential for normal gene expression regulation and various biological processes [5]. It is associated with multiple pathways such as the MAPK/ERK pathway [1].

In various disease models, Cpsf1 shows diverse functions. In a diabetic retinopathy model, down-regulation of Cpsf1 was observed in diabetic tissues and high-glucose-induced human retinal vascular endothelial cells. Up-regulation of Cpsf1 alleviated apoptosis and migration via the MAPK/ERK pathway [1]. In Caenorhabditis elegans, circ-CPSF1 (a circular RNA related to Cpsf1) was found to have deleterious effects on lifespan, eggs production and germ cell apoptosis through oxidative stress after ionizing radiation [2]. In gastric cancer, Cpsf1 is up-regulated, and its depletion weakened cell proliferation and metastasis. Cpsf1 positively regulates NSDHL by APA to promote cancer progression [3]. In prostate cancer, Cpsf1 is up-regulated in advanced cases, and its knockdown inhibited cell growth, reduced glycolytic output, and led to widespread use of intergenic poly(A) sites [4].

In conclusion, Cpsf1 is essential for regulating gene expression through APA and is involved in multiple biological processes and disease conditions. Studies using different models, including disease-specific cell models and animal models like zebrafish and C. elegans, have revealed its role in diseases such as diabetic retinopathy, radiation-induced injury, and various cancers, providing insights into potential therapeutic targets.

References:
1. Zhang, Jingyi, Zhang, Xi, Zou, Yuanyuan, Han, Fengmei. 2020. CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway. In Archives of physiology and biochemistry, 128, 708-715. doi:10.1080/13813455.2020.1722704. https://pubmed.ncbi.nlm.nih.gov/32046510/
2. Yuan, Jing, Lin, Fei, Wu, Zhiyong, Li, Li, Zhang, Chao. 2023. Circ-CPSF1 Worsens Radiation-Induced Oxidative Stress Injury in Caenorhabditis elegans. In Biomolecules, 13, . doi:10.3390/biom13010102. https://pubmed.ncbi.nlm.nih.gov/36671487/
3. Kang, Weibiao, Yang, Yang, Chen, Changyu, Yu, Changjun. 2022. CPSF1 positively regulates NSDHL by alternative polyadenylation and promotes gastric cancer progression. In American journal of cancer research, 12, 4566-4583. doi:. https://pubmed.ncbi.nlm.nih.gov/36381317/
4. Tietz, Kiel T, McCluskey, Braedan M, Miller, Conor R, Munro, Sarah A, Dehm, Scott M. 2025. CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells. In Cell reports, 44, 115211. doi:10.1016/j.celrep.2024.115211. https://pubmed.ncbi.nlm.nih.gov/39847481/
5. Bolli, Niccolò, Payne, Elspeth M, Rhodes, Jennifer, Zon, Leonard I, Look, A Thomas. 2011. cpsf1 is required for definitive HSC survival in zebrafish. In Blood, 117, 3996-4007. doi:10.1182/blood-2010-08-304030. https://pubmed.ncbi.nlm.nih.gov/21330472/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest