White Paper
Animal Models of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) and Steatohepatitis (MASH)
This white paper explores key animal models used in the study of MASLD and MASH, providing insights into their design, relevance, and application in preclinical research.
Overview
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly NAFLD, is the most prevalent chronic liver disease worldwide, often progressing to MASH and end-stage liver diseases. This white paper reviews MASLD/MASH pathophysiology and introduces major animal models including diet-induced, chemically induced, genetically modified, and composite types.
Key Insights
Discover how different types of animal models support MASLD/MASH research, from disease mechanism exploration to therapeutic evaluation.
- Introduction of MASLD and MASH
- Classification of animal models: diet-induced, chemical, genetic, composite
- Most commonly used composite models
- Clinical relevance and translational value of different model types
- Application in studying pathogenesis and therapeutic validation
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